Chinese  |  English
Home / PatientCare / Internal Medicine System

Department Details

Kidney Disease Center

1. History


    The Kidney Disease Center originated from the Kidney Transplant Blood Purification Center (started from Urology Surgery and the Nephrology Group of Internal Medicine Department. In 1974, a Dialysis Room was established with a three-member team (the principal Zhu Cong, the nurse Xu Min and the engineer Zhu Lizhong), who conducted dialysis treatment for chronic renal failure (CRF) and delivered training to rotary doctors, refresher doctors and nurses. From the first kidney transplantation on July 14, 1977, until 1981, the team performed 14 cases, with the longest patient surviving for nine-and-a-half years. The year 1981 witnessed the initial foundation of an expert panel on kidney disease in Zhejiang, which was also one of the units responsible for establishing the Kidney Disease Branch of the Zhejiang Medical Association. In the same year, the first renal biopsy was successfully conducted by the panel. In August 1984, the Hemodialysis Room was set up and this was moved to the first floor of the seven-floor specialist building, with a department comprising the director Zhu Cong, three doctors (Wang Yimin, Chen Jianghua and Ye Youxin), the head nurse Xu Min and three staff nurses (Gu Yaqin, Chen Shuiyun and Lv Peijun), two technicians (Zhu Lizhong and Wu Turong), with access to eight artificial kidney hemodialysis machines and eight beds. This year also saw the establishment of continuous blood purification (CBP) technology. In June 1985, the first case of acute severe hepatitis and hepatic coma was successfully treated through bedside blood purification. This treatment was further enhanced with the later cooperation of the Infectious Diseases Department and produced obvious clinical effects that were rewarded with the "Medical Science & Technology Progress Award of Zhejiang Province (first class)" and "Science & Technology Progress Award of Zhejiang Province (first class)" in 1997, and the "National Science & Technology Progress Award (second class)" in 1998. In 1986, more than 1,000 dialysis procedures were being conducted successfully in one year. By May 1989, with the maturity of the dialysis technology and the medical team, allograft renal transplantation was resumed under the direction of Urology Surgery, and in September Chen Jianghua returned to the department having finished his postgraduate education program. In May 1991, the Hemodialysis Room was renamed as the Hemodialysis Center, and the Kidney Transplant Blood Purification Center was established in November of that year with 32 specialized personnel and access to 20 dialysis machines and 12 beds. Zhu Cong acted as the director of this Center, with Chen Jianhua as the deputy director, while Chen Shuiyun and Zhu Liya acted as the head nurse and deputy head nurse, respectively. The establishment of this Center allowed independent kidney transplantation operations to be performed, and by 1992, a mature operation team had been formed, completing 107 transplantation procedures. In 1993, the Information Room was set up at the Center . In May 1995, Zhu Cong was approved as the master supervisor and recruited Wu Jianyong as his first student. In May 1996, Chen Jianhua was appointed as the director of the Kidney Transplant Blood Purification Center, which was staffed by 20 medical personnel with access to 16 beds. By this time, the Center had completed 103 kidney transplants, being the first facility to conduct 100 procedures in one year and being at the forefront of the National kidney transplant scheme. In the same year, in collaboration with the Hepatobiliary Surgery Department, the Center successfully studied simultaneous pancreas-kidney transplantation (SPKT) and received the "National Science & Technology Progress Award (second class)". The recipient of this pioneering transplant is the longest surviving patient post-operatively recorded in Asia. In June the Communist Party branch was organized by Wu Jianyong as the secretary and Zhu Cong as the deputy secretary to provide support for independent branch activities and the development of the Department. The number of transplant cases reached 161 by 1997, representing the highest number of procedures conducted in hospitals around China during that year. Chen Jianhua, as one of the first-tier members of the "151 Talents Project" in Zhejiang Province, was elected as the master supervisor in urology in 1998. The year 1998 also saw receipt of the "Medical Science & Technology Progress Award of Zhejiang Province (first class)" for the "Clinical Research on Allograft Kidney Transplantation" presided over by Chen Jianghua. By 1999, international academic exchanges were started with Shou Zhangfei going abroad funded by the government scholarship. In the same year, the Youth League Branch and the Party Branch of the Center was named the "Advanced Youth League Branch of Zhejiang Province" and the "Advanced Party Branch of Zhejiang Province" separately, and furthermore, the department became the first in the hospital to be awarded the title "Youth Civilized Collectivity in Zhejiang Province". On January 5, 2000, the first living related donor kidney transplantation was successfully carried out at the Center.

    In July 2000, the hospital combined the Kidney Transplant Blood Purification Center and the Nephrology Group into Kidney Disease Center. Chen Jianghua was appointed as the Center Director and Zhu Liya as the head nurse, with the number of beds increased to 91 and the number of dialysis machines, to 28. The Center had 76 medical staff and comprised a kidney transplant ward, a kidney disease ward, a blood purification treatment area, a kidney disease laboratory and an outpatients' department. The establishment of this facility provided appropriate treatment to all kidney disease patients at an early, middle or late stage, and established the clinical practice of integrated therapy for kidney diseases. The number of transplants conducted at this Center reached 1000 cases by September 29, 2000. In October, Lin Weiqin and Wu Jianyong were appointed as the deputy Directors, with Zhu Liya, Yuan Jing and Cai Qiuqin appointed as head nurses for the kidney disease ward, the blood purification treatment area, and the kidney transplant ward respectively, with Wu Jianyong as the secretary of the Party Branch. In the year 2000, recorded 10000 blood purification procedures conducted over the history of the Center. In December 2000, Chen Jianghua, who was approved as the doctoral supervisor on urology and academic convener, began recruiting doctoral students as transplant professionals within the urology surgery department. Led by Professor Chen Jianghua, the Kidney Disease Department of the Internal Medicine of Zhejiang University, School of Medicine launched the postgraduate programs and Ph.D programs in 2001 and 2002, with Professor Chen as the academic convener and the double-discipline doctoral supervisor for surgery (urology) and internal medicine (kidney disease). In 2000, the "Clinical Study on Simultaneous Hepatorenal Transplantation", led by Professor Chen was awarded the "National Science & Technology Progress Award (first class)", and in 2001 the first combined heart and kidney transplantation in Zhejiang Province was successfully performed with the cooperation of the Zhejiang Provincial People's Hospital, and this patient survives still.

    The establishment of the Center not only conferred advantages of discipline and size, but also increased the numbers of visiting patients. To follow up the development, in May 2001, 37 beds and one Peritoneal Dialysis Treatment Room were added and a Comprehensive Division was created. Yin Xiaohong joined the division as a head nurse. With 128 beds, 54 hemodialysis machines and eight multi-functional blood purification machines, the Center became one of the largest integrated therapy centers for kidney diseases in China. In the laboratory of the center, serum concentrations of FK506, RAPA and MPA were monitored, clinical analysis of factors such as PRA, AIAP, anti-GMB antibodies, hematuria osmotic pressure and calculus was conducted. The evaluation of kidney and transplantation pathology was fully developed, and a clinical specimens database was established, as well as the generation of animal models kidney disease and transplantation. The laboratory was also an important research base for postgraduates. In 2003, the Center welcomed Doctor He Qiang, the first Ph.D candidate to be jointly educated by this department and the Urinary Surgery Department, and Wu Jianyong became the postgraduate supervisor in the same year. It also conducted "Clinical Research on Combined Heart and Kidney Transplantation from the Same Donor", gaining the "Medical Science & Technology Progress Award of Zhejiang Province (first class)". Its academic status in China was further acknowledged when the "2004 National Kidney Academic Conference" was held in Hangzhou in October of that year, which was the largest and most successful conference on kidney diseases in history. This year, it secured approval and formed two key disciplines in Zhejiang medical science-Nephrology and the Integrated Traditional and Western Nephrology in Zhejiang Province. In that July, Zhang Ping, the first Ph.D graduate to be independently educated by this program joined the Center, and three staff (Shou Zhangfei, Chen Yilun and Wang Huiping) became the postgraduate supervisors in the same year. The number of transplantations completed by the Center reached 200 cases in 2004. In 2005, the hospital merged with the Hangzhou Railway Center Hospital and to form the First Affiliated Hospital of Medical School of Zhejiang University, Chenzhan Campus, and the Hemodialysis Room of the campus was integrated into the Center. In that October, Chen Jianghua was appointed as the Deputy Party Secretary and the Secretary of CPC Central Committee for Discipline Inspection, and the year also saw the department named as the "Zhejiang Provincial Professional Ethics Demonstration Group". By the end of 2005, the Center had completed more than 2000 transplantation procedures. In 2006, the department was recognized as the "Outstanding Youth Civilization Service Model of Zhejiang Province". The hospital made some adjustments among middle-level managers: Chen Jianghua was appointed as Center Director in addition to his former posts, with Wu Jianyong and Shou Zhangfei as the deputy Directors, He Qiang, as the Branch Secretary, and Wu Jianyong, as the third secretary of the CPC General Branch. In March 2007, the Center became the first department in the hospital to be recognized as the "National Youth Civilization Service Model". In May, the Zhejiang Center for Hemodialysis Quality Control was established and affiliated to this department, with Chen Jianghua as the Director and He Qiang, Zhang Ping and Yuan Jing as the deputy Directors. In July the Party General Branch was awarded the title "Advanced Grass-roots Party Organization of Zhejiang University" and in September the Center became one of the designated units for organ transplantation under the Ministry of Public Health. The whole Center moved into the Block 6 with 122 beds and 102 hemodialysis machines and multi-functional blood purification machines. Meanwhile, the Chenzhan Division was reconstructed separately with access to 18 beds and 12 hemodialysis machines. Its 300 m2 Professor's. laboratory was officially opened for use in the Zhejianag University Zijin Campus. He Qiang was elected as the master supervisor. By September 2008, the Center performed the first successful kidney transplantation combined donor hematopoietic stem cell transfusion in China and the patient in this case has survived two-and-a-half years after successfully stopping the use of immunosuppressant drugs. Its Party branch was honored as the "Innovative Grass-rooted Party General Branch of Zhejiang Universities" and the "Advanced Party General Branch of the First Affiliated Hospital of Medical School of Zhejiang University".. The "Establishment of a Digital Model for Kidney Transplant Receptor and Preparation of Related Biological Chip" led by Chen Jianghua won the "Science & Technology Progress Award of Zhejiang Province (first class)". From September 2008 to February 2010, Shou Zhanhui, who was among the sixth batch of carders to provide aid for Xinjiang, went to the Medical School of Shihezi University as the vice-president, and gained the second highest honor awarded by the Xinjiang Production and Construction Corps. In July 2009, the laboratory in this Center was rated as the "Immunology (Kidney Diseases) Laboratory (third class) of the State Chinese Medicine Administration Bureau" by the state bureau, which marked a brand-new step in the construction of disciplinary science and research. The first donation after cardiac death (DCD) kidney transplantation was successfully performed on October 11, 2010 (by July 30, 2012, the Center had performed 52 DCD kidney transplantations, ranking first in China), and in the same year, Li Yiwen and Tian Jiong were approved as supervisors of doctoral students and postgraduates. The number of transplantation procedures reached 3000 by January 13, 2011, and the ten-year survival rate of the cured patients reached 81.7%, taking the world lead. In 2011, Han Fei and Peng Wenhan became supervisors of postgraduates, and Wu Jianyong held a concurrent post as the vice-president of Kecheng People's Hospital in Quzhou City, while He Qiang acted as the vice-president of the First Affiliated Hospital of Medical School of Zhejiang University, Beilun Campus. In January 2012, the laboratory was assessed as the "Key Laboratory on Kidney Diseases Prevention Technologies and Research in Zhejiang Province"; and in June, was successfully evaluated as the State Key Clinical Department, which demonstrated that the overall strength of the discipline was the best in China. In March, Jiang Hua was elected as the Secretary of the Party General Branch. This year also saw Zhang Ping and Jiang Hong becoming supervisors of postgraduates and Shou Zhangfei becoming the doctoral supervisor of the clinical specialty.

    The discipline advantage was boosted with the establishment of the Center, thus enhancing the influence of the academic leaders and strength of the academic circle. For example, Professor Chen Jianghua held the post of committee member of the Chinese Medical Association, Organ Transplantation Branch, of the China Society of Dialysis Transplantation Research, of the Chinese Medical Association, Kidney Disease Branch in 2001 and 2002, followed by his role as chairman of the Zhejiang Society of Biomedical Engineering, Artificial Kidney Board and the China Society of Dialysis Transplantation Research, Zhejaing Branch in 2003. In the same year, Wu Jianyong became vice-chairman and secretary of the Zhejiang Society of Biomedical Engineering, Artificial Kidney Board, while He Qiang and Yuan Jing were elected as members of the board. Wang Yiming became vice-chairman of the China Society of Dialysis Transplantation Research, Zhejaing Branch, where He Qiang, Zhang Ping, Yuan Jing, Yin Xiaohong and Cai Qiuqing were members. In 2004, Professor Chen Jianghua acted as chairman of the Zhejiang Medical Association, Kidney Disease Branch, standing committee member of the Chinese Medical Association, Kidney Disease Branch and vice-chairman of the Kidney Disease Cooperating Group in Eastern China; while Lin Weiqin and He Qiang served as standing committee member and secretary, respectively, of the Chinese Medical Association, Kidney Disease Branch, and Shou Zhangfei as the youth member of the Chinese Medical Association, Organ Transplantation Branch. Professor Chen was appointed for another term as chairman of the Zhejiang Medical Association, Kidney Disease Branch in December 2009, where He Qiang and Tian Jiong acted as secretaries. In August 2011, when the first committee of the Zhejiang Doctor's Association, Nephrology Physician Branch was founded, Professor Chen was elected as chairman, and He Qiang and Tian Jiong as secretary-general and secretary, respectively. The Zhejiang Branch of the Organ Transplantation was re-elected in 2011, with Professor Chen as vice-chairman and Shou Zhangfei as the standing member of the branch. In January 2012, Professor Chen was elected as vice-chairman of the 9th Chinese Medical Association, Kidney Disease Branch, and in June, acted as the deputy editor-in-chief of the Chinese Journal of Nephrology. He was also appointed as the secretary-general of the Chinese Medical Association, Organ Transplantation Branch. The year 2012 saw the establishment of the 1st Youth Members of the Organ Transplantation Branch, with Shou Zhangfei as the secretary-general. After decades of hard work, the Nephrology Department, with its fully developed and increased academic levels, has been highly acknowledged by its international counterparts. Professor Chen, the academic leader of the department, won the International Distinguished Medal (only four people in the world have received this medal) issued by the American National Kidney Foundation (NKF).

    By the end of July 2012, the Center had 224 staff, including 55 doctors, 153 nurses, three engineers and technicians, and 13 laboratory researchers. Among these are, eight are professors or senior doctors, 13 associate professors or associate senior doctors, one associate chief technician, three doctoral supervisors and nine postgraduate supervisors.


2. Medical Work


    In October 1967, the rotating drum artificial kidney machine (TYPE B), developed by Kolff-Nenck was first used at the Center for hemodialysis in cases of acute kidney failure. The failure was treated by peritoneal dialysis the following year. In 1974, the Urology Dialysis Room was founded and NIKKIS0 ST, BN-2000, Wutian TMl01 Artificial Kidney Machines and the Kill Flat-Type Dialyzer were introduced to treat uremia in CRF. In 1976, as directed by the Provincial Science Society, the Center began to study the dialysate adsorbent, which was later applied in the clinic. On July 14, 1977, the first Human Allograft (non-living donor) Kidney Transplantation was performed, and in 1979, the Provincial Health Department approved the first Certificate for the Use of Non-living Organs in Zhejiang Province, and the yearly dialysis numbers exceeded 100 for the first time. In 1981, the Nephrology Group was established and the first kidney puncture biopsies were conducted. In 1982, four Gambro AK-10 artificial kidney machines were introduced from Sweden, and by 1983 the first patient with CRF had survived for 20 years after sustained dialysis. Subsequently, artificial kidney dialysis became a conventional treatment and was available for outpatients. In August 1984, the Hemodialysis Room was set up and four more Gambro AK-10 hemodialysis machines were introduced. Then, with a total of eight artificial kidney hemodialysis machines and 12 beds, the survival rate after treatment for acute/chronic kidney failures was obviously increased. Meanwhile, new technologies such as Continuous Arterio-Venous Hemofiltration (CAVH) and hemoperfusion were used to treat disorders such as multiple organ failure, severe hepatitis and hepatic failure. In June 1985, the first acute severe hepatitis and hepatic coma patient was cured through blood purification. By the end of 1986, more than 1000 dialysis procedures were being performed yearly. Compared to 14 kidney transplantation operations with the longest survival of nine-and-a-half years that were achieved before 1981, the dialysis technology and medical team were experienced enough to resume allograft kidney transplantation in May 1989 with the support of Urology Department, and in November autogenous saphenous vein, non-living donor arteries and artery and vein fistula transplanted by artificial vas were successively performed for the first time in the Province. In October 1990, the Center first applied the technologies of standard hemofiltration and membrane plasma separator. The following May, the Hemodialysis Center was established, forming the foundation of the Blood Purification Center builded in November 1993, and in June, hemodiafiltration technology was first used to prevent long-term complications in patients with chronic dialysis. In August with dialysis anticoagulation technology monitored by non-anticoagulation hemodialysis and ACT, blood purification therapy for acute/chronic kidney failure and the rate for rescue of high-risk bleeding patients were further increased. Blood purification treatments reached more than 2000 that year, and the yearly kidney transplantation procedures reached 30 cases with a yearly survival rate of 93%, reaching the criteria set by the National Transplantation Center. In December 1992, for the first time in Zhejiang Province, the Center employed second-membrane plasma separator technology to treat severe autoimmune diseases and kidney transplantation rejection. In January 1993, ascites-hemodialysis (filtration) direct-returning technology was first used in China to treat the refractory ascites in connection with dialysis. The third simultaneous pancreas-kidney transplantation (SPKT) was jointly performed with the Department of Hepatobiliary and Pancreatic Surgery in April 1994, resulting in the longest period of survival following transplantation in both China and the whole of Asia by far. In January 1995, the most advanced Gambro Ultra 100 blood purification machine was introduced and used to carry out the first use of HDF on-line technology in China. In November, it launched the first renal capsulotomy and hemostatic satin hemostasis in China that was supported by second-membrane plasma separator technology and anti-lymphocyte globulin (ALG), with the reversal rate against acute humoral rejection of kidney transplantation at an early stage was over 90%. By 1996 and 1997, the number of transplantations was 103 and 161 respectively, both listed as the first among its counterparts in China, and the yearly blood purification treatments in 1996 reached groundbreaking rates of 5000. In March 1999, specific immune tolerance technology using simultaneous kidney-bone marrow transplantation was applied in the clinic. Using this technology, more than 100 cases of simultaneous kidney-bone marrow transplantations have been completed so far, and the acute rejection incidence has been reduced by 50%. The first patient treated with simultaneous hepatorenal transplantation in 1999, which was supported by the Department of Hepatobiliary Surgery, is still alive. On January 5, 2000 the Center successfully conducted the first living related donor kidney transplantation, and the year also witnessed the combined heart and kidney transplantation that was jointly performed with Zhejiang Provincial People's Hospital and this patient is still alive. In 2004, the Center first reached a record of over 200 kidney transplantations. In October, with the introduction of water treatment equipment focusing on heat disinfection from Gambro Company, the Center became the first to establish the dialysis criteria of germ-free and apyrogenity in the Asia Pacific region. By December 25, 2005, the total number transplantations topped 2000 cases. In 2007, the Center became one of the designated units for organ transplantations under the Ministry of Public Health, thus starting the standardized development of the work in the department. In 2008, the first non-myeloablative kidney-bone marrow transplantation to induce tolerance in the clinic was performed in China, creating the first case of long-term survival of a recipient without the use of immunosuppressive agents (to date the patient has survived for two-and-a-half years after stopping immunosuppressive agents). Since October 11, 2010, the Center has completed 52 cases of kidney transplantation following organ DCD (ranking the first in China). In 2011, it completed 100 cases of living related donor kidney transplantations, accounting for 35.7% of the total kidney transplantations of this type in the year (it was 442 cases as of July 30, 2012), and took the lead among its counterparts in China, with 280 cases of total kidney transplantations. In 2001, with the cooperation of the Zhejiang Provincial People's Hospital, it successfully performed the first combined heart and kidney transplantation in Zhejiang Province and the patient is still alive.

    Over the last thirty years, with several generations of hard work, the Center created a new approach to treatment; integrated therapy for kidney disease. To date, the Center has completed more than 70,000 cases of hemodialysis every year with over 90% of the patients surviving for one year after treatment and 70% surviving for five-years after treatment. Annually, over 400 severe patients have been treated with CRRT, and 3,615 cases have been cured. The survival rate of patients with acute renal failure in perioperative period of liver transplantation has been improved from 30.0% to 51.7%, and that of MODS combined with severe infections has increased from 27.4% to 38.5%. Of those CRS patients experiencing failure of diuretic therapy and patients suffering from severe acute pancreatitis, the 28-day survival rate has reached 53.3% and 83% separately. Every year, the Center performs over 1,000 cases of blood purification access surgery, assists other hospitals in treating more than 600 patients for vascular access and complications, and conducts 1,400 cases of kidney biopsies. To date, the longest surviving patient at the end-stage renal disease has been alive for over 28 years after integrated treatment. The number of visiting peritoneal dialysis patients has reached 500 cases, with one-year and five-year survival rates exceeding 90% and 70%, respectively. In 2011, the Center became one of the first demonstration units for peritoneal dialysis assigned by the Ministry of Health, and created the hierarchical network management platform of the Zhejiang Peritoneal Dialysis Center. At present, the Center has completed more than 3,400 kidney transplantations and established four systems which ensure an internationally advanced level of one-year (>95%) and then-year (>80%) survival rates. These four systems are: the warning and diagnosis system of acute renal transplant rejection, the individualized immune intervention system after kidney transplantation, the system for prevention of special infection after kidney transplantation and the system for prevention of chronic allograft nephopathy. The department had carried out an earlier exploration of the application of new immunodepressants in refractory kidney diseases: in 1998 it began to use mycophenolate mofetil to treat lupus nephritis; in 2000 tacrolimus was used to treat the lupus nephritis and refractory nephritic syndromes, and from 2002, a combination of hormone, tacrolimus and mycophenolate mofetil was used as a multi-target immunosuppressive agent to treat refractory lupus nephritis. Furthermore, related research findings were delivered in internationally recognized journals, such as the American Journal of Kidney Diseases and the American Journal of Nephrology and Nephrology Dialysis Transplantation, which were quoted in the 2012, KIDIGO Guide. The Center also launched the multi-Center RCT study (Tamer study) in China using tacrolimus alone to treat minimal-change nephritic.


3. Science & Research


    In 1957, led by Yang Songsen, the director of Urology Surgery, the Center first launched its program of experimental research on kidney transplantation in animals (sheep) and the basic experimental study on the artificial kidney-resulting in the development of the dialyzer. In 1960 it developed a series of academic activities related to acute kidney failure. In October 1967, for the first time, it used the Kolff-Nenck B revolving-drum artificial kidney machine to perform hemodialysis treatment for acute kidney failure, and in 1968 applied peritoneal dialysis to deal with such failure. In 1972 the Center took on an assignment from the Zhejiang Science and Technology Committee to research type-I and type-II artificial kidney machines. In 1978, the FT peritoneal dialysis machine (funded by the Zhejiang Science and Technology Committee) was successfully developed, and following provincial appraisal was awarded the "Science and Technology Award" issued by the Ministry of Health. In 1980, the "Artificial Kidney Dialysate Heat Exchange Energy Saver" passed a related appraisal. The Zhejiang type-II Artificial Kidney Machine and the type-79 blood pump, which were designed by the Zhejiang Science and Technology Committee, won the "Science & Technology Progress Award of Zhejiang Province (third class)" in 1979 and 1981, and the resulting ZID-06 medical-use electrodialysis water treatment machine was awarded the "Excellent New Product Prize" by the National Ministry of Light Industry in 1982. In October 1992, it undertook "Research on Fibronectin in Kidney Transplantation and Blood Purification", a project that was funded by the Health Department of Zhejiang Province, and won the "Medical Science & Technology Progress Award of Zhejiang Province (second class)" and the "Science & Technology Progress Award of Zhejiang Province (third class)" in 1996. In June 1993, "Research on Inflammatory Mediator Clearance in Multiple Organ Failure (MSOD) Rescue" funded by the same department was started. Since April 1994, it had cooperated with the Department of Hepatobiliary and Pancreatic Surgery on the  simultaneous pancreas-kidney transplantation (SPKT), and finally won the "Medical Science & Technology Progress Award of Zhejiang Province (first class)", the "Science & Technology Progress Award of Zhejiang Province (first class)", and the "National Science & Technology Progress Award (second class)" in 1995 and 1996. In 1995, Double Filtration Plasmapheresis (DFPP) was first used in China to treat vascular and refractory rejection after kidney transplantation, supported by desensitizing antibody treatment before surgery. The result showed that the rate of reversal of refractory and vascular rejection after kidney transplantation reached over 90%, winning the "Medical Innovation Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (second class)" in 2002. In June 1996, studies on "Cytomegalovirus Infection and Kidney Transplantation" and "Research on Induced Immune Tolerance for Allograft Kidney Transplantation Recipient" were undertaken, separately funded by the Health Department of Zhejiang Province and Zhejiang Education Commission. The year 1997 saw 161 cases of kidney transplantation, ranking the first among the hospitals of China, and in March, Chen Jianghua's work was published in international journals collected by SCI, representing the first author to achieve this in this area. In 1997 the "Clinical Research on Kidney Transplantation" had passed the appraisal of the internationally recognized experts in China, and won the "Medical and Health Science & Technology Progress Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (first class)" in 1998. Its research on "Treating Severe Viral Hepatitis using an Artificial Liver Support System", a joint project with the Infectious Diseases Department, had won the "Medical Science & Technology Progress Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (first class)" in 1997 and the "National Science & Technology Progress Award (second class)" in 1998.

    Since its establishment in 2000, the Center led by Professor Chen Jianghua has achieved significant advances in scientific research. The joint research on simultaneous pancreas-kidney transplantation (SPKT) with the Department of Hepatobiliary Surgery, as well as the combined heart and kidney transplantation undertaken with the provincial People's Hospital were awarded the "Medical Innovation Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (first class)" in 2000 and 2003, respectively. Furthermore the study on early diagnosis of cytomegalovirus infection in transplant recipients won the "Medical Innovation Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (second class)" in 2003. By 2005, renal replacement therapy for chronic end-stage renal disease was deemed to meet internationally advanced standards, and thus won the "Medical Innovation Award of Zhejiang Province (first class)" and the "Science & Technology Progress Award of Zhejiang Province (second class)" in 2006. In 2007, senior doctor Li Xiayu took part in the "Evaluation Study on the Results of Treating systemic Lupus Erythematosus by Removing Toxin Stasis and Nourishing the Kidney", the National Eleventh-Five Year Scientific and Technical Supporting Program (sub-topic) and was awarded the "Science & Technology Progress Award of Zhejiang Province (first class)". In 2008, the establishment of the "Digital Model for Kidney Transplant Receptor and Preparation of Related Biological Chip" won the "Science & Technology Progress Award of Zhejiang Province (first class)", and the same year the Center also participated in the National Eleventh-Five Year Scientific and Technical Supporting Program (Key Technology Study on Organ Transplantation-the development and research on key diagnosis technology for anti-rejection reactions), and in 2011, joined the 973 Projection (sub-topic) (Key Factors and Signal Pathway for Embryo Kidney Mesenchymal Cell Differentiating to Epithelia). In the same year, Professor Chen Jianghua led one of the topics of the National Twelfth-Five Year Scientific and Technical Supporting Programs, "Proper Diagnosis and Treatment Technology of Acute Renal Injury", which was the breakthrough for the Center in presiding over key scientific and research projects in China. In November, the Kidney Disease Laboratory was listed the Key Laboratory on Kidney Disease Prevention Technologies and Research in Zhejiang Province. In 2012, the Center participated in the 973 Projection (sub-topic) (Studies on Mechanisms by which miRNA Leads to Glomerulus Injury).

    Papers published: since the discipline was established, the Center has published more than 350 papers in national and provincial medical journals and 85 papers were collected by the SCI as the first author, among which, papers written by Jiang Hong, the associate researcher, have been published in world class journals like Nature Genetics and the Proceedings of the National Academy of Sciences of the United States of America as the first and second authors. This has furthered the influence of the Center in academic circles. In 2011, the Center 25 papers had been collected by the SCI, with the total impact factor scoring 54.32, ranking number 3 in the nephrology specialty of China.

    There are over 100 topics that have been closed and studied, and 17 key interdisciplinary projects. Twelve of these are supported by the National Natural Science Fund: "Preventing Organ Rejection Reaction by SHARP-2 Gene-specific RNA Interference with Adenovirus as Carrier" studied by Shou Zhangfei in 2005 filled in the blanks in projects under National Natural Science Foundation. In 2007, Chen Jianghua led the research on "Evaluation of Haemodynamics and Oxygenation State of Transplanted Kidney and Impact Mechanism of Complication after Transplantation". During the last five years, the Center has obtained more than RMB 30 million for research funds. Now the discipline comprises clinical and fundamental research approaches, such as immunologic surveillance and tolerance induction after kidney transplantation, the development and promotion of new blood purification technology, management of hemodialysis and peritoneal dialysis and their quality improvement, diagnosis of refractory kidney diseases, and newly immunosuppressive therapy.


4. Teaching


    Postgraduate training and education: provide class and clinical teaching on nephrology for seven-year program students, undergraduates, overseas students, and junior college students. In May 1995, Zhu Cong was approved as postgraduate supervisor and recruited Wu Jianyong in the same year as the first student to be trained in this department. In 1998, Chen Jianghua became the postgraduate supervisor of Urology Surgery. In December 2000, he was elected as the doctoral supervisor and academic convener of Urology Surgery, and began to recruit his first doctoral students majoring in transplantation. Zhang Ping was the first student to be independently educated in this department, obtained a doctoral degree in 2004. Led by Professor Chen Jianghua, the Kidney Disease Department of the Faculty of Internal Medicine, Zhejiang University, School of Medicine, launched postgraduate and Ph.D programs in 2001 and 2002, with Professor Chen as the academic convener and the double-discipline doctoral supervisor for surgery (urology) and internal medicine (kidney disease). In September 2001, two postdoctoral researchers (Jin Zhongda and Zhu Hengcheng) became involved in basic research of kidney diseases. Later the team of postgraduate supervisors was strengthened with the introduction of Wu Jianyong (2003), Shou Zhangfei (2004), Chen Yilun (2004), Wang Huiping (2004), He Qiang (2007), Tian Jiong (2010), Han Fei (2011), Peng Wenhan (2011), Jiang Hong (2012) and Zhang Ping (2012). In 2010 Li Yiwen was approved as the doctoral supervisor, and Shou Zhangfei became the supervisor for clinical doctoral degrees in 2012. In 2007, the department was approved as the training base for nephrology specialist physicians by the Department of Health.

    To date, the Center has already educated five postdoctoral candidates, 20 medical doctoral students, 49 postgraduates, and more than 40 students in Master's and doctoral programs.

    Teaching materials compilation: took part in the compilation of teaching materials and books, such as, 7-year textbooks Nephrology and Internal Medicine, Nephrology for Postgraduates, Chinese Kidney Transplantation Handbook, Therapeutics for Kidney Transplantation, Handbook of Kidney Transplantation, Standard Operating Procedures for Blood Purification, Standard Operating Procedures for Peritoneal Dialysis, Clinical Transplantation, Frontiers in Transplantation, Stubborn Diseases in Internal Medicine, Pancreas Transplantation, and Perioperative Treatment for Liver Transplantation.


5. Directors of the Center


    Zhu Cong (served from August 1984 to June 1996)

    Zhu Cong was the founder of the Kidney Transplantation Blood Purification Center. After graduating from the Department of Medicine, Zhejiang Medical University in 1959, Zhu Cong was assigned to this hospital, working in the Department of Urology Surgery. He began to study the acute renal failures and multiple organ dysfunction syndromes caused by critical diseases in 1961, and further developed and promoted the research, production and verification of the therapy and articles for blood .He also established the Zhejiang Dialysis Therapy Network in the same year. From 1967, he acted as the head of the Artificial Kidney Dialysis Group and the main member of the clinical kidney transplantation team. He began to perform clinical kidney transplantation in 1977 and became the director of the Hemodialysis Room in 1984. From 1991, he was responsible for the Blood Purification Center. In 1989, he founded the Zhejiang Society of Biomedical Engineering, Artificial Kidney Board, acting as the chairman. In 1992 he founded the China Society of Dialysis Transplantation Research, Zhejaing Branch and acted as the chairman of the branch. In November 1993, he was appointed as the director of the Kidney Transplantation Blood Purification Center. In 1994, as the deputy director of the Zhejiang Organ Transplantation Center, he collaborated with the Department of Hepatobiliary Surgery on the simultaneous pancreas-kidney transplantation (SPKT). He was the key person in charge of the clinical project "Home-made Immunosuppressant-Ciclosporin" from 1992 to 1994, and since 2001 has acted as the deputy editor of Hepatobiliary & Pancreatic Diseases International (English Version), consulting editor of the Chinese Journal of Transplantation (Electronic Version), and health care practitioner for the teams of the Health Department of Zhejiang Province. During his nearly half-a-century working in the hospital, he accumulated vast experience in treating kidney urological diseases, kidney replacement, multiple organ function support therapy and organ transplantations, and wrote and published more than 80 works and papers. He has contributed greatly to the development of kidney disease therapy and organ transplantation in China, and was awarded one "Science & Technology Progress Award" issued by the National Ministry of Health in 1978, and two "Science & Technology Progress Awards of Zhejiang Province (second class)" in 1979; three "Science & Technology Progress Awards of Zhejiang Province (first class)" and one "National Science & Technology Progress Award" in 1996 and 1998.


    Chen Jianghua (Serving from July 1996…)

    Chen Jianghua obtained his first degree awarded by Zhang Medical University in March 1980 and then conducted clinical and scientific research on kidney diseases. In 1989 he graduated from Tianjin Medical University and obtained Master's degree. He is now the Deputy Party Secretary and the Secretary of CPC Central Committee for Discipline Inspection, and the director of the Kidney Disease Center at the First Affiliated Hospital of Medical School of Zhejiang University; the academic leader of the Nephrology Department in Zhejiang University, School of Medicine, senior doctor and doctoral supervisor. He excels in the areas of kidney disease treatment, blood purification and kidney transplantation. He proposed and promoted the innovative idea of integrated therapy for kidney disease in China, which has driven the rapid development of this discipline.

    Professor Chen is the vice-chairman of the Chinese Medical Association, Kidney Disease Branch, the secretary-general of the Chinese Medical Association, Organ Transplantation Branch, the vice-chairman of the Kidney Disease Cooperating Group in Eastern China, the standing director of Zhejiang Medical Association, Kidney Disease Branch, the chairman of Zhejiang Medical Association, Kidney Disease Branch, the vice-director of the Chinese Medical Association, Organ Transplantation Branch, the director of the China Society of Biomedical Engineering and the standing director of the Zhejiang Branch, the chairman of the Artificial Kidney Board and the China Society of Dialysis Transplantation Research, Zhejiang Branch, the director of Zhejiang Center for Hemodialysis Quality Control and chairman of the Committee of Experts, and the director of the Key Laboratory on Kidney Diseases Prevention Technologies and Research in Zhejiang Province.

    Following clinical practice, Chen Jianghua focused clinical studies and basic research and has made the following achievements: as a project leader, he obtained the "Science & Technology Progress Award of Zhejiang Province (two separate first and second class awards)" and one "Science & Technology Progress Award of Zhejiang Province (third class)"; as the main participant he obtained two "National Science & Technology Progress Awards (second class)", five "Science & Technology Progress Awards of Zhejiang Province (first class), one "Science & Technology Progress Award of Zhejiang Province (second class) and two "Science & Technology Progress Awards of Zhejiang Province (third class)"; he has published more than 300 papers in nationally and internationally professional journals. His endeavors have significantly improved the clinical and academic level in the discipline of nephrology. He is now the deputy editor-in-chief of the Chinese Journal of Nephrology, standing member of the editorial board of the Chinese Journal of Practical Internal Medicine and the Chinese Journal of Transplantation, and editorial board member of the Chinese Journal of Organ Transplantation, the Chinese Journal of Nephrology Dialysis & Transplantation and the World Journal of Clinical Urology.

    Professor Chen was awarded a special government allowance of the State Council, and was elected as one of the first-tier members of the "151 Talents Project" in Zhejiang Province and listed in the national "Talents Project". He was designated "Outstanding Communist of Zhejiang Universities", "One Hundred Excellent Doctors in china", "Outstanding Communist of Zhejiang Province" ,"Young- and Middle-aged Experts with Outstanding Contributions in Zhejiang Province", "Young- and Middle-aged Scientific & Technological Experts with Outstanding Contributions (awarded by the Ministry of Health) ", "Doctor Bethune in China" by the Zhejiang government , "Advanced Scientists and Technologists in Zhejiang Province". He also won the "2008 Advanced Individuals in the National Health System", the "2011 Advanced Scientists and Technologists in Zhejiang Province" and was named among the "Excellent Party Affairs Workers of Zhejiang University in 2012". Due to his remarkable achievements in clinical practice and has academic status concerning the integrated therapy for kidney diseases, Professor Chen was awarded the International Distinguished Medal (only four people in the world have received this medal) by the American National Kidney Foundation (NKF), which is a high recognition among these international counterparts.

网站故障联系电话:(0571)87236648   备案号:浙ICP备05050873号   设计制作:杭州卓健信息科技有限公司