个人简介

周舟，教授、博士生导师，现任浙江大学医学院公共卫生学院环境医学系主任，浙大一院急诊科双聘教授。国家优秀青年基金获得者，国家973项目课题负责人。浙江大学"百人计划"引进人才，2017年入选香港“王宽诚教育基金青年学者”。

专业擅长

职业与环境有害因素毒性效应、毒理作用机制与防护新策略研究。

研究方向

1. 重金属及其纳米颗粒暴露毒理作用机理与防护研究。 2. 职业与环境有害理化因素暴露与疾病关联研究。 3. 新型内源性活性小分子化合物拮抗职业与环境有害理化因素健康危害的筛选与评估。

成果奖项：（近五年主要成果及奖励情况）

1. Yu Xi, Mengyu Liu, Shuzhen Xu, Huihui Hong, Mengyan Chen, Li Tian, Jia Xie, Ping Deng , Chao Zhou, Lei Zhang, Mindi He, Chunhai Chen, Yonghui Lu, Russel J. Reiter, Zhengping Yu, Huifeng Pi, Zhou Zhou*.Inhibition of SERPINA3N‐dependent neuroinflammation is essential for melatonin to ameliorate trimethyltin chloride– induced neurotoxicity. Journal of Pineal Research, 2019, 67(3). DOI: 10.1111/jpi.12596.

2.  Pi H, Li M, Zou L, Yang M, Deng P, Fan T, Liu M, Tian L, Tu M, Xie J, Chen M, Li H, Xi Y, Zhang L, He M, Lu Y, Chen C, Zhang T,Wang Z, Yu Z, Gao F, Zhou Z*. AKT inhibition-mediated dephosphorylation of TFE3 promotes overactive autophagy independent of MTORC1 in cadmium-exposed bone mesenchymal stem cells. Autophagy. 2019, 15(4)，565–582.

3. Huifeng Pi, Mengyu Liu, Yu Xi, Mengyan Chen, Li Tian, Jia Xie, Mingliang Chen, Zhen Wang, Min Yang, Zhengping Yu, Zhou Zhou*, and Feng Gao*. Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery. The FASEB Journal.2019, 33(11):fj.201900812R.

4.  Huifeng Pi, Zhen Wang, Mengyu Liu, Ping Deng, Zhengping Yu, Zhou Zhou*, Feng Gao*. SCD1 activation impedes foam cell formation by inducing lipophagy in oxLDL‐treated human vascular smooth muscle cells. Journal of Cellular and Molecular Medicine.2019, 23(4).

5. Pi H, Li M, Xie J, Yang Z, Xi Y, Yu Z, Zhou Z*. Transcription factor E3 protects against cadmium-induced apoptosis by maintaining the lysosomal-mitochondrial axis but not autophagic flux in Neuro-2a cells. Toxicol Lett. 2018 Oct 1;295:335-350.

6. Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He1,Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou*. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. Journal of Pineal Research. 2018:e12457. doi: 10.1111/jpi.12457.

7.  Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He,Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou*. Inhibiting MT2-TFE3-dependent autophagy enhances melatonin-induced apoptosis in tongue squamous cell carcinoma. J. Pineal Res. 2017;e12457. doi.org/10.1111/jpi.12457.

8.  Chunhai Chen, Qinglong Ma, Ping Deng, Jianjing Yang, Lingling Yang, Min Lin, Zhengping Yu, Zhou Zhou*. Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development. BBA - Molecular Cell Research.  2017;1864:1900–1912.

9.  Qian Li, Min-Di He, Lin Mao, Xue Wang, Yu-Lin Jiang, Min Li, Yong-Hui Lu, Zheng-Ping Yu,  Zhou Zhou*. Nicotinamide N-Methyltransferase Suppression Participates in Nickel-Induced Histone H3 Lysine9 Dimethylation in BEAS- 2B Cells. Cell Physiol Biochem 2017;41:2016-2026.

10.  Huifeng Pi, Min Li, Li Tian, Zhiqi Yang, Zhengping Yu & Zhou Zhou*.  Enhancing lysosomal biogenesis and autophagic fux by activating the transcription factor EB protects against cadmium-induced neurotoxicity. Scientific Reports, 2017;7:43466,DOI: 10.1038/srep43466.

11. Zhengwang Cao, Yiliang Fang, Yonghui Lu, Dunxian Tan, Changhong Du, Yuming Li, Qinlong Ma,Junmei Yu, Mengyan Chen, Chao Zhou,Liping Pei, Lei Zhang,Haiying Ran,Mindi He,Zhengping Yu, Zhou Zhou*. Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome. J. Pineal Res. 2017;doi:10.1111/jpi.12389.

12. Zhou Zhou*, Yong-hui Lu, Hui-feng Pi, Peng Gao, Min Li, Lei Zhang, Li-ping Pei, Xiang Mei, Lin Liu, Qi Zhao, Qi-Zhong Qin, Yu Chen,Yue-ming Jiang, Zhao-hui Zhang, Zheng-ping Yu. Cadmium Exposure is Associated with the Prevalence of Dyslipidemia. Cell Physiol Biochem. 2016, 40:633-643.

13. Min Yang, Huifeng Pi, Min Li, Shangcheng Xu, Lei Zhang, Jia Xie, Li Tian, Manyu Tu, Mindi He, Yonghui Lu, Zhengping Yu, and Zhou Zhou*. Autophagy Induction Contributes to Cadmium Toxicity in Mesenchymal Stem Cells via AMPK/FOXO3a/BECN1 Signaling. TOXICOLOGICAL SCIENCES, 2016, 154(1):101–114.  The cover paper.

14. Zhi-Yu Chen, Chuan Liu, Yong-hui Lu, Ling-Ling Yang, Min Li, Min-Di He, Chun-Hai Chen, Lei Zhang, Zheng-Ping Yu, Zhou Zhou*. Cadmium Exposure Enhances Bisphenol A-Induced Genotoxicity through 8-Oxoguanine-DNA Glycosylase-1 OGG1 Inhibition in NIH3T3 Fibroblast Cells. Cell Physiol Biochem 2016;39:961-974.

15. Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Min Yang, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou*. Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy–lysosome machinery in mouse neuroblastoma cells. J. Pineal Res. 2016; 61（3）:353-369.

16. Zhengwang Cao, Yiliang Fang, Yonghui Lu, Fenghua Qian, Qinglong Ma, Mingdi He, Huifeng Pi, Zhengping Yu, Zhou Zhou*. Exposure to nickel oxide nanoparticle induces pulmonary inflammation through NLRP3 inflammasome activation in rats. International journal of nanomedicine. 2016:11,3331-3346.

17. Kuan Zhang, Chunhai Chen, Zhiqi Yang, Wenjing He, Xiang Liao, Qinlong Ma, Ping Deng, Jian Lu, Jingcheng Li, Meng Wang, Mingli Li, Lianghong Zheng, Zhuan Zhou, Wei Sun, Liting Wang, Hongbo Jia, Zhengping Yu, Zhou Zhou* and Xiaowei Chen. Sensory response of transplanted astrocytes in adult mammalian cortex in vivo. Cerebral Cortex, 2016,1-15. The cover paper.

18. Min Li, Chuan Liu, Lingling Yang, Lei Zhang, Chunhai Chen, Mindi He, Yonghui Lu, Wei Feng, Huifeng Pi, Yanwen Zhang, Min Zhong, Zhengping Yu, Zhou Zhou*. G9a-mediated histone methylation regulates cadmium-induced male fertility damage in pubertal mice. Toxicology Letters. 2016, 252:11–21.

19. Yonghui Lu, Shangcheng Xu, Haiyan Chen, Mindi He, Youcai Deng, Zhengwang Cao, Huifeng Pi, Chunhai Chen, Min Li, Qinlong Ma, Peng Gao, Yan Ji, Lei Zhang, Zhengping Yu, Zhou Zhou*. CdSe/ZnS quantum dots induce hepatocyte pyroptosis and liver inflammation via NLRP3 inflammasome activation. Biomaterials. 2016, 90:27-39

20. Haiyan Chen Yonghui Lu Zhengwang Cao Qinlong, Ma Huifeng Pi Yiliang Fang Zhengping Yu Houxiang Hu, Zhou Zhou*. Cadmium Induces NLRP3 Inflammasome-dependent Pyroptosis in Vascular Endothelial Cells. Toxicology letters. 2016, 246:7-16.

21. Shangcheng Xu*, Huifeng Pi, Lei Zhang, Nixian Zhang, YuMing Li, Huiliang Zhang, Ju Tang, Huijuan Li, Min Feng, Pan Guo, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Wang Wang, Russel J. Reiter, Zhengping Yu, Zhou Zhou*. Melatonin prevents abnormal mitochondrial dynamics resulting from the neurotoxicity of cadmium by blocking calcium-dependent translocation of Drp1 to the mitochondria. J. Pineal Res. 2016,60:291-302.

22. Chuan Liu,Peng Qian, Lingling Yang, Lei Zhang, Chunhai Chen, Mindi He, Yonghui Lu, Wei Feng,Min Li, Yanwen Zhang, Min Zhong, Zhengping Yu, Zhou Zhou*. Pubertal exposure to di-(2-ethylhexyl)-phthalate inhibits G9a-mediated histone methylation during spermatogenesis in mice. Archive of toxicology, 2016, 90 (4) :1-15.

23. Huifeng Pi,Shangcheng Xu, Russel J Reiter, Pan Guo, Lei Zhang, Yuming Li, Min Li, Zhenwang Cao, Li Tian,Jia Xie, Ruiqi Zhang, Mindi He, Yonghui Lu, Chuan Liu, Weixia Duan, Zhengping Yu, and Zhou Zhou*.  SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin. Autophagy. 2015 ,11(7):1037-51.

24. Duan WX, He MD, Mao L, Qian FH, Li YM, Pi HF, Liu C, Chen CH, Lu YH, Cao ZW, Zhang L, Yu ZP, Zhou Zhou*. NiO nanoparticles induce apoptosis through repressing SIRT1 in human bronchial epithelial cells.Toxicol Appl Pharmacol. 2015, 286:80-91.

25. Weixia Duan, Chuan Liu, Lei Zhang, Mindi He, Shangcheng Xu, Chunhai Chen, Huifeng Pi, Peng Gao, Yanwen Zhang, Min Zhong, Zhengping Yu, and Zhou Zhou*.  Comparison of the Genotoxic Effects Induced by 50 Hz Extremely Low-Frequency Electromagnetic Fields and 1800 MHz Radiofrequency Electromagnetic Fields in GC-2 Cells.Radiation research, 2015,183(3) 305-314.

    
    

社会任职

现任国际职业卫生学会委员，中华预防医学会卫生毒理学会副主任委员，中国毒理学会生物标志物专业委员会副主任委员，中国诱变剂学会生物标志物专业委员会副主任委员，中国毒理学会工业毒理学专业委员会常委，中国生物医学工程生物电磁专业委员会常委，中国生物物理学会辐射与环境专业委员会委员。