个人简介

 浙江大学医学院附属第一医院特聘研究员，硕士研究生导师。本科毕业于华中科技大学药学院，于2013年在浙江大学医学院硕博连读，主要研究课题为骨关节炎病理性力学信号介导分子及其干预用于骨关节炎治疗的研究，获干细胞与再生医学专业博士学位。2018年至2022年在浙江大学欧阳宏伟教授课题组从事博士后研究，主要课题为骨损伤再生过程中关键干细胞亚群的鉴定与再生机制研究。2023年起加入浙江大学医学院附属第一医院任特聘研究员。长期从事基于生物活性成分及干细胞的骨、软骨组织工程方面的研究。已在Nature Communications、Biomaterials、Advanced Healthcare Materials、Acta biomateralia、ACS Applied Materials & Interfaces、Journal of Orthopaedic Translation等SCI期刊发表学术论文24篇，累计被引用次数超过1179次，H指数12。

研究方向

基于骨骼干细胞亚群和生物活性材料的骨组织工程研究；基于单细胞多组学解析骨再生过程中再生细胞事件的研究等。

成果奖项：（近五年主要成果及奖励情况）

1） Xianzhu Zhang#, Wei Jiang#, Chang Xie#, Xinyu Wu, Qian Ren, Fei Wang, Xilin Shen, Yi Hong, Hongwei Wu, Youguo Liao, Yi Zhang, Renjie Liang, Wei Sun, Yuqing Gu, Tao Zhang, Yishan Chen, Wei Wei, Shufang Zhang, Weiguo Zou, Hongwei Ouyang*. Msx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration. Nature Communications. 2022. Sep 5;13(1):5211.

2） Xianzhu Zhang, Dandan Cai, Feifei Zhou, Jie Yu, Xinyu Wu, Dongsheng Yu, Yiwei Zou, Yi Hong, Chunhui Yuan, Yishan Chen, Zongyou Pan, Varitsara Bunpetch, Heng Sun, Chengrui An, Toh Yi-Chin, Hongwei Ouyang*, Shufang Zhang*. Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis. Biomaterials. 2020 Feb;232:119724.

3） Chang Xie#, Renjie Liang#, Jinchun Ye#, Zhi Peng, Qiuwen Zhu, Xilin Shen, Yi Hong, Hongwei Wu, Wei Sun, Xudong Yao, Jiajin Li, Shufang Zhang, Xianzhu Zhang*(Co-corresponding), Hongwei Ouyang*. High-efficient engineering of osteo-callus organoids for rapid bone regeneration within one month. Biomaterials. 2022 Sep;288:121741. 

4） Jingwei Zhang#, Xianzhu Zhang#(Co-first author), Yi Hong, Qianbao Fu, Qiulin He, Asma Mechakra, Qiuwen Zhu, Feifei Zhou, Renjie Liang, Chenglin Li, Yejun Hu, Yiwei Zou, Shufang Zhang, Hongwei Ouyang*. Tissue-Adhesive Paint of Silk Micro-particles for Articular Surface Cartilage Regeneration. ACS Appl. Mater. Interfaces. 2020, 12, 20, 22467–22478. 

5） Feifei Zhou#, Xianzhu Zhang#(Co-first author), Dandna Cai, Jun Li, Qin Mu, Wei Zhang, Shouan Zhu, Yangzi Jiang, Weiliang Shen, Shufang Zhang*, Hongwei Ouyang. Silk Fibroin-Chondroitin Sulfate Scaffold with Immuno-inhibition Property for Articular Cartilage Repair. Acta Biomater, 2017 Nov;63:64-75.

6） Wei, Wei#; Ma, Yuanzhu#; Zhang, Xianzhu#(Co-first author); Zhou, Wenyan#; Wu, Hongwei; Zhang, Jingwei; Lin, Ju nxin; Tang, Chenqi; Liao, Youguo; Li, Chenglin; Wang, Xiaozhao; Yao, Xudong; Koh, Yi Wen; Huang, Wenwen; Hongwei Ouyang*; Biomimetic Joint Paint for Efficient Cartilage Repair by Simultaneously Regulating Cartilage Degeneration and Regeneration in Pigs. ACS Appl Mater Interfaces, 2021, 13( 46): 54801-54816.

Chang Xie; Jinchun Ye; Renjie Liang; Xudong Yao; Xinyu Wu; Yiwen Koh; Wei Wei; Xianzhu Zhang*(Co-corresponding); Hongwei Ouyang*; Advanced Strategies of Biomimetic Tissue-Engineered Grafts for Bone Regeneration. Advanced Healthcare Materials, 2021, 10(14). 

社会任职

中国生物医学工程学会会员；Journal of Visualized Experiemnts期刊客座编辑，ACS Biomaterials Science & Engineering， iScience等国际知名期刊特邀评审专家。