个人简介
美国科罗拉多州立大学博士，浙江大学博士后，传染病重症诊治全国重点实验室助理研究员，蛋白质谱平台负责人，生物大分子质谱应用专家，研究方向为生物质谱检测方法的开发，采用蛋白/代谢组学手段开发疾病标志物研发并开展感染性疾病机制研究。先后于MCP、JCI、Anal Chem、Engineering、Theranostics等组学、医学及化学TOP期刊上发表41篇SCI文章。先后主持中国博士后基金一项、国家自然科学基金2项、国家重点研发计划子任务2项、浙江省医药卫生科技计划各一项，参与863计划，国家重点研发计划及自然科学基金多项。
专业擅长
擅长大分子生物质谱技术应用，蛋白组学与翻译后修饰组学，感染性疾病与重症化感染标志物开发，病原体-宿主互作机制研究。蛋白组生物信息学软件和多组学大数据统计流程。
研究方向
重症肝炎预警标志物和发病机制研究；利用蛋白组学和翻译后修饰组学挖掘病毒-宿主作用靶标与机制研究；代谢物调控免疫与炎症反应的机制研究；新型大分子生物质谱技术开发与应用研究。
成果奖项：（近五年主要成果及奖励情况）
Daxian Wu#, Sainan Zhang#, Er’mei Chen, Qunfang Rao, Xiaoli Liu, Zhongyang Xie, Kaizhou Huang, Jing Yang, Lanlan Xiao, Feiyang Ji, Zhengyi Jiang, Yalei Zhao, Xiaoxi Ouyang, Danhua Zhu, Xiahong Dai, Zhouhua Hou, Bingjie Liu, Binbin Deng, Ning Zhou, Hainv Gao, Zeyu Sun*, Lanjuan Li*, Plasminogen as a prognostic biomarker for HBV-related acute-on-chronic liver failure, Journal of Clinical Investigation, 2020, Apr 1;130(4):2069-2080. (IF：14.8)
Zeyu Sun#, Wei Li#, Jialu Xu, Keyi Ren, Feng Gao, Feiyang Ji, Dongli Pan*, Proteomic analysis of cerebrospinal fluid in children with acute enterovirus-associated meningoencephalitis identifies dysregulated host processes and potential biomarkers, Journal of Proteome Research, Jul 17, 2020.19, 8:3487–3498 (IF：4.5)
Zhengyi Jiang#, Zeyu Sun#, Xiaoxi Ouyang#, Yalei Zhao#, Menghao Zhou, Baohong Wang, Qirui Li, Linxiao Fan, Sainan Zhang, Lanjuan Li*, Temporal Integrative Omics Reveals an Increase in Nondegradative Ubiquitylation during Primary Hepatocyte Dedifferentiation, Engineering, 2020, Nov, 6(11), 1302-1314 (IF：7.5)
Zeyu Sun, Keyi Ren, Xing Zhang, Jinghua Chen, Zhengyi Jiang, Jing Jiang, Feiyang Ji, Xiaoxi Ouyang, Lanjuan Li*. Mass spectrometry analysis of newly emerging coronavirus HCoV-19 spike protein and human ACE2 reveals camouflaging glycans and unique post-translational modifications, Engineering, 2021, Oct , 7(10), 1441-1451 (IF：12.8)
Pengyan Wang, Can Yue, Kefang Liu, Dan Lu, Sai Liu, Sijia Yao, Xiaoling Su, Keyi Ren, Yan Chai, Jianxun Qi, Yongliang Lou, Zeyu Sun*, George Gao*, William Liu*, Peptide presentations of marsupial MHC I visualize immune features of lower mammals paralleled with bats, The Journal of Immunology, 2021, Oct 15;207(8):2167-2178. (IF：5.4)
Zeyu Sun#, Xiaoqin Zheng#, Feiyang Ji, Menghao Zhou, Xiaoling Su, Keyi Ren, Lanjuan Li*, Mass Spectrometry Analysis of Coronavirus SARS-CoV-2 Nucleocapsid Protein Reveals Camouflaging Glycans and Unique Post-Translational Modifications, Infectious Microbes and Diseases, 2021, 3(3):149-157
Feiyang Ji#, Menghao Zhou#, Zeyu Sun#, Zhengyi Jiang#, Huihui Zhu, Zhongyang Xie, Xiaoxi Ouyang, Lingjian Zhang, Lanjuan Li*, Integrative proteomics reveals the role of E3 ubiquitin ligase SYVN1 in hepatocellular carcinoma metastasis, Cancer Communications, 2021 Oct;41(10):1007-1023. (IF：10.4)
Zeyu Sun#, Chenjie Huang#, Yixian Shi, Rusha Wang, Jun Fan, Ye Yu, Zhehua Zhang, Kundan Zhu, Minwei Li, Qin Ni, Zhi Chen, Min Zheng*, Zhenggang Yang*, Distinct bile acid profiles in patient with chronic hepatitis B virus infection reveal metabolic interplay between host, virus and gut microbiome, Frontiers of Medicine, 2021, Oct 4, 8:708495 (IF：4.6)
Xiaoqin Zheng#, Zeyu Sun#, Liang Yu, Danrong Shi, Miaojin Zhu, Hangping Yao*, Lanjuan Li*, Interactome analysis of the nucleocapsid protein of SARS-CoV-2 virus, Pathogens, 2021, Sep 8;10(9):1155 (IF：3.5)
Yinping Tian#, Qiang Zhu#, Zeyu Sun#, Didi Geng, Bingyi Lin, Xiaoling Su, Jiahui He, Miao Guo, Hong Xu, Ye Zhao, Weijie Qin, Peng George Wang, Liuqing Wen, Wen Yi, One-step enzymatic labeling reveals a critical role of O-GlcNAcylation in cell-cycle progression and DNA damage response, Angewandte Chemie, 2021, Dec 6;60(50):26128-26135. (IF：12.9)
Jialu Xu#, Zeyu Sun#, Wei Li, Lifang Liu, Feng Gao, Dongli Pan*, Epidemiological characteristics and cerebrospinal fluid cytokine profiles of enterovirus encephalitis in children in Hangzhou, China, Journal of Medical Virology, 2022, Jun;94(6):2645-2652. (IF：2.3)
Fujun Hou#, Zeyu Sun#, Yue Deng, Siyu Chen, Xiyuan Yang, Ji Feiyang, Menghao Zhou, Keyi Ren, Dongli Pan*, Interactome and ubiquitinome analyses identify functional targets of herpes simpex virus 1 ICP0, Frontiers in Microbiology, 2022, Apr 18;13:856471 (IF：5.6)
Daxian Wu, Qunfang Rao, Zhongyang Xie, Xiaoqing Zhu, Yuanmei Che, Jian Wu, Hainv Gao, Jingyu Zhang, Zhouhua Hou, Xiaoyu Cheng*, Zeyu Sun*, Decreased vitamin D-binding protein level portends poor outcome in acute-on-chronic liver failure caused by hepatitis B virus, Clinical and Molecular Hepatology, 2022 Oct;28(4):912-925. doi: 10.3350/cmh.2022.0121
Qixia Luo, Yu Wang, Xiaoling Su, Xue Yang, Zeyu Sun*, Proteomic characterization of human gut habitual Bacteroides intestinalis against common intestinal bile acids stress, Advanced Gut & Microbiome Research, 2023, May 23; 8395946
Huili Liu, Jun Wang, Yan Zhang, Jing Gu, Yu Wang, Yongxing Yan*, Dongli Pan*, Zeyu Sun*, Cerebrospinal fluid proteomics in meningitis patients with reactivated varicella zoster virus, Immunity, Inflammation and Disease, 2023 Oct;11(10):e1038. doi: 10.1002/iid3.1038 (IF：3.2)
Yang Yu, Peng Sun, Yan Liu, Wan-lu Zhao, Teng-jian Wang, Shuang-xia Yu, Lin-Kun Tian, Lin Zhao, Min-min Zhang, Qiao-yan Zhang, Ze-yu Sun*, Quanlong Zhang*, Lu-ping Qin*, Characterization and evaluation of the in vitro and in vivo anti-diabetic activities of camel milk protein hydrolysates derived with different protease digestions, Journal of Functional Foods, 2024:106227 (IF：5.6)
Jianing Zhang, Can Yue, Yin Lin, Jinmin Tian, Yuanyuan Gao, Danni Zhang, Yanxin Guo, Beiwei Ye, Yan Chai, Jianxun Qi, Yingze Zhao, George Gao*, Zeyu Sun*, Jun Liu*, Uncommon P1 Anchor-featured Viral T Cell Epitope Preference within HLA-A*2601 and HLA-A*0101 Individuals, ImmunoHorizons, 2024, Jun 1;8(6):415-430.
2023年度中华医学科技奖《重要疫源微生物组的研究与发现》
2024年 浙江省第四届“检测家杯”优秀论文奖《基于高分辨质谱和从头测序算法的蛋白SUMO组学研究》
2020/2021/2023 浙江大学医学院先进工作者
社会任职
浙江省分析测试协会生物大分子专委会，常委；浙江省数理医学学会生物医学大数据专委会委员；中国转化医学联盟暨中国精准医学学会 会员；美国化学工程师协会(AIChE)，会员；美国质谱学会(ASMS)，会员; Journal of Proteome Research, Molecular and Cellular Biochemistry, 中国细胞生物学学报，Frontiers in Bioscience-Landmark, BMC Genomics等审稿人
