个人简介

上海交通大学临床检验诊断学专业博士，浙江大学医学院特聘副研究员，主管技师。研究方向为多功能核酸适体分子靶向药物用于光动力增强的结直肠癌协同治疗，聚焦于功能核酸在靶向蛋白降解和免疫阻断治疗相关研究。目前主持国家自然科学基金青年项目，浙江省自然科学青年基金和浙大一院青年A类。近5年已发表SCI论文18篇，其中第一作者（含共同第一作者）11篇，10分以上6篇，单篇最高影响因子为 29.4 分，申报发明专利多项。主要为Journal of The American Chemical Society，ACS Nano，Nano Today，CCS Chemistry，Nanoscale，Advanced Materials（2篇），Journal of agricultural and food chemistry，International Journal of Biological Macromolecules，Chinese Chemical Letters等。

专业擅长

作为浙江大学医学院特聘副研究员和科室科研攻坚主力，在临床工作中发掘科学问题，推动多功能核酸适体在结直肠癌中的诊疗一体化研究

研究方向

多功能核酸适体分子靶向药物用于光动力增强的结直肠癌协同治疗

功能核酸在靶向PD-L1蛋白降解和结直肠癌免疫阻断治疗相关研究

成果奖项：（近五年主要成果及奖励情况）

1、主持科研项目：

1）国家自然科学基金青年项目，30万元，2026.1-2028.12；

2）浙江省自然科学青年基金项目，10万元，2025.1-2026.12

2、科研论文（第一作者/共同第一作者）：

1、Rongjun Zhang（章荣俊）, Changjie Yang, Xiaobo Gao, Zhenyang He, Ding-Kun Ji, and Weihong Tan. Phototriggered LYTAC: Photoactive Bispecific Aptamer Chimera Enhances Targeted Degradation of Membrane Protein through Regulating Cell Autophagy [J]. J. Am. Chem. Soc. 2025, 147, 20989-21002. (JCR Q1区TOP，共同第一作者).

2、Rongjun Zhang（章荣俊）, Lihao Guo, Qingjiao Li, Yin Liang, Yingying Liao, Huibin Xu, Chutong Liu, Gandong Zhou, Li Wang, Shuxiang Xu, and Miaomiao Yuan. Biodegradable Carrier-Free Nanomedicine via Self-Assembly of Pure Drug Molecules for Triple Sensitization of Radiotherapy [J]. ACS Nano. 2025, 19, 16355-16371. (JCR Q1区TOP，共同第一作者).

3、Rongjun Zhang（章荣俊）, Weihong Tan, Ding-Kun Ji. DNA aptamer-empowered self-assembly full-API nanodrug for enhanced photodynamic and chemotherapy synergistic cancer therapy. Nano today. 2024.57.102399. (JCR Q1区TOP，第一作者).

4、Rongjun Zhang（章荣俊）, Ding-Kun Ji, Defan Yao, Zeyu Xiao, Weihong Tan. Molecular Engineering of Aptamer to Solubilize Hydrophobic NIR Photosensitizer for Enhanced Cancer Photodynamic Therapy [J]. CCS Chemistry. 2023.6:1240-1254 (JCR Q1区TOP，共同第一作者).

5、Rongjun Zhang（章荣俊）, Shuxiang Xu, Miaomiao Yuan, Lihao Guo, Luoyijun Xie, Yingying Liao, Yang Xu and Xuemei Fu. An ultrasmall PVP-Fe-Cu-Ni-S nano-agent for synergistic cancer therapy through triggering ferroptosis and autophagy [J]. Nanoscale, 2023, 15, 12598-12611 (JCR Q1区，共同第一作者).

6、Ning Tang, Rongjun Zhang（章荣俊）, Youbin Zheng, Jing Wang, Muhammad Khatib, Xue Jiang, Cheng Zhou, Rawan Omar, Walaa Saliba, Weiwei Wu, Miaomiao Yuan*, Daxiang Cui*, Hossam Haick*. Highly Efficient Self-Healing Multifunctional Dressing with Antibacterial Activity for Sutureless Wound Closure and Infected Wound Monitoring [J]. Advanced Materials. 2022, 34(3) :e2106842. (JCR Q1区TOP，共同第一作者).

7、Youbin Zheng, Rawan Omar, Rongjun Zhang（章荣俊）, Ning Tang, Muhammad Khatib, Qi Xu, Yana Milyutin, Walaa Saliba, Yoav Y Broza, Weiwei Wu, Miaomiao Yuan*, and Hossam Haick*. Wearable Microneedle-Based Extended Gate Transistor for Real-Time Detection of Sodium in Interstitial Fluids [J]. Advanced Materials. 2022, 34(10):e2108607. (JCR Q1区TOP，共同第一作者).

8、Rongjun Zhang（章荣俊）, Youbing Zheng, Tianqing Liu, Ning Tang, Lianzhi Mao, Lihan Lin, Jiahui Ye, Luoyijun Xie, Wenwen Hu, Weiwei Wu, Wenzhen Liao, Miaomiao Yuan. The marriage of sealant agent between structure transformable silk fibroin and traditional Chinese medicine for faster skin repair [J]. Chinese Chemical Letters. 2022,33(03):1599-1603(JCR Q1区TOP，共同第一作者).

9、Rongjun Zhang（章荣俊）, Yuan Sijie, Ye Jufeng, Wang Xiangdong, Zhang Xudong, Shen Jie, Yuan Miaomiao, Liao Wenzhen. Polysaccharide from flammuliana velutipes improves colitis via regulation of colonic microbial dysbiosis and inflammatory responses [J]. International Journal of Biological Macromolecules, 2020,149: 1252-1261 (JCR Q1区TOP，共同第一作者).

10、Rongjun Zhang（章荣俊）, Chen Jian, Mao Lianzhi, Guo Yajie, Hao Yuting, Deng Yudi, Han Xue, Li Qingjiao, Liao Wenzhen, Yuan Miaomiao. Nobiletin Triggers Reactive Oxygen Species-Mediated Pyroptosis through Regulating Autophagy in Ovarian Cancer Cells [J]. Journal of agricultural and food chemistry, 2020, 68(5): 1326-1336 (JCR Q1区TOP，共同第一作者)