个人简介

 浙江大学“百人计划（临床医学）”研究员、博士生导师。获武汉大学外科学博士与法国Paris-Saclay大学肿瘤学博士学位。从事肿瘤免疫原性与免疫监视的基础及临床转化研究。采用分子细胞生物学、遗传学及肿瘤模式动物等手段研究: (1)肿瘤免疫原性的来源及调控机制; (2) 神经-代谢-免疫复杂网络在肿瘤进展中的作用; (3) 抗肿瘤药物筛选及分子药理机制。近年来以第一/通讯作者（含共同）在 Signal Transduct Target Ther (2X)、J Hematol Oncol (2X, 高引论文)、J Immunother Cancer以及eLife等期刊发表论文20余篇，总引用超4000次，H指数29。获上海市“浦江人才计划”支持，主持国家自然科学基金青年及面上项目。

专业擅长

 擅长肝内胆管癌诊治

研究方向

  围绕肿瘤抗原的产生、鉴定、调控及识别机制展开研究。关注情绪、睡眠、饮食、运动、肥胖、衰老等宏观应激因素如何调控肿瘤免疫原性与免疫监视功能，旨在系统解析其在肿瘤发生发展中的作用机制。

成果奖项：（近五年主要成果及奖励情况）

近五年主要成果:

1. Yu, X., Li, W., Feng, H., Li, Z., Zheng, H., Sun, S., Li, J., Li, B., and Wu, Q. (2026). A mediterranean-mimicking diet harnesses gut microbiota–derived 3-IAA to rejuvenate T cell. eLife.

2. Gao, Z., Liu, Y., Cui, Y., Han, Y., Cao, K., and Wu, Q. (2025). The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology. J. Adv. Res., S2090-1232(25)00649-6.

3. Yu, X., Pei, W., Li, B., Sun, S., Li, W., and Wu, Q. (2025). Immunosenescence, Physical Exercise, and their Implications in Tumor Immunity and Immunotherapy. Int. J. Biol. Sci. 21, 910–939.

4. Gao, Z.-J., Fang, H., Sun, S., Liu, S.-Q., Fang, Z., Liu, Z., Li, B., Wang, P., Sun, S.-R., Meng, X.-Y., et al. (2024). Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype. Theranostics 14, 3104–3126.

5. Wu, Q., Liu, Z., Li, B., Liu, Y., and Wang, P. (2024). Immunoregulation in cancer-associated cachexia. J. Adv. Res. 58, 45–62.

6. Yu, X., Li, W., Li, Z., Wu, Q., and Sun, S. (2024). Influence of Microbiota on Tumor Immunotherapy. Int. J. Biol. Sci. 20, 2264–2294.

7. Liu, S.-Q., Chen, D.-Y., Li, B., Gao, Z.-J., Feng, H.-F., Yu, X., Liu, Z., Wang, Y., Li, W.-G., Sun, S., et al. (2023). Single-cell analysis of white adipose tissue reveals the tumor-promoting adipocyte subtypes. J. Transl. Med. 21, 470.

8. Yu, X., Tian, A.-L., Wang, P., Li, J., Wu, J., Li, B., Liu, Z., Liu, S., Gao, Z., Sun, S., et al. (2023). Macrolide antibiotics activate the integrated stress response and promote tumor proliferation. Cell Stress 7, 20–33.

9. Li, B., Sun, S., Li, J.-J., Yuan, J.-P., Sun, S.-R., and Wu, Q. (2023). Adipose tissue macrophages: implications for obesity-associated cancer. Mil. Med. Res. 10, 1.

10. Li, B., Liu, S., Yang, Q., Li, Z., Li, J., Wu, J., Sun, S., Xu, Z., Sun, S., and Wu, Q. (2023). Macrophages in Tumor-Associated Adipose Microenvironment Accelerate Tumor Progression. Adv. Biol. 7, e2200161.

11. Wu, Q., Liu, Z., Gao, Z., Luo, Y., Li, F., Yang, C., Wang, T., Meng, X., Chen, H., Li, J., et al. (2023). KLF5 inhibition potentiates anti-PD1 efficacy by enhancing CD8+ T-cell-dependent antitumor immunity. Theranostics 13, 1381–1400.

12. Liu, Z., Gao, Z., Li, B., Li, J., Ou, Y., Yu, X., Zhang, Z., Liu, S., Fu, X., Jin, H., et al. (2022). Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression. OncoImmunology 11, 2085432.

13. Wu, Q., Gao, Z.-J., Yu, X., and Wang, P. (2022). Dietary regulation in health and disease. Signal Transduct. Target. Ther. 7, 252. https://doi.org/10.1038/s41392-022-01104-w.

14. Liu, S.-Q., Gao, Z.-J., Wu, J., Zheng, H.-M., Li, B., Sun, S., Meng, X.-Y., and Wu, Q. (2022). Single-cell and spatially resolved analysis uncovers cell heterogeneity of breast cancer. J. Hematol. Oncol.J Hematol Oncol 15, 19. https://doi.org/10.1186/s13045-022-01236-0.

15. Wu, Q., Zhang, H., Sun, S., Wang, L., and Sun, S. (2021). Extracellular vesicles and immunogenic stress in cancer. Cell Death Dis. 12, 894.

16. Wu, Q., Yu, X., Li, J., Sun, S., and Tu, Y. (2021). Metabolic regulation in the immune response to cancer. Cancer Commun Lond 41, 661–694.

17. Wu, Q., Tian, A.-L., Li, B., Leduc, M., Forveille, S., Hamley, P., Galloway, W., Xie, W., Liu, P., Zhao, L., et al. (2021). IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. J. Immunother. Cancer 9, e002722.

18. Wu, Q., Yu, X., Liu, L., Sun, S., and Sun, S. (2021). Centrosome-phagy: implications for human diseases. Cell Biosci. 11, 49.

19. Wu, Q., Li, B., Li, J., Sun, S., Yuan, J., and Sun, S. (2021). Cancer-associated adipocytes as immunomodulators in cancer. Biomark. Res. 9, 2.

20. Tian, A.-L., Wu, Q., Liu, P., Zhao, L., Martins, I., Kepp, O., Leduc, M., and Kroemer, G. (2021). Lysosomotropic agents including azithromycin, chloroquine and hydroxychloroquine activate the integrated stress response. Cell Death Dis. 12, 6.

主要承担科研项目:

1. 益生菌Akkermansia muciniphila产生尿石素A改善肿瘤免疫监视的机制研究,国家自然科学基金委员会, 面上项目，49万元，2024-01-01 至 2027-12-31，主持

2. 肿瘤相关脂肪细胞通过腺苷抑制效应T细胞促进结肠癌进展的机制研究,国家自然科学基金委员会, 青年科学基金项目, 30万，2023-01-01 至 2025-12-31，主持

3. 肿瘤相关脂肪细胞促进结肠癌进展的机制研究，上海市人事局和上海市科学技术委员会, 上海市浦江人才计划，30万元，2022-10 至 2024-10，主持

4. 应激感应蛋白OTUD4调控核糖体稳态促进肿瘤免疫原性的机制和治疗策略，同济大学自主原创基础研究项目，12万元, 2024-04-01至2026-03-31，主持

奖励情况:

华夏医学科技奖，乳腺癌血标志物的筛选及生物学机制探索 三等奖，中国医院保健国际交流促进会，2024年12月，吴奇

社会任职

担任Exploration、iMeta、Advanced Biology和Military Medical Research编委