个人简介
浙江大学临床医学七年制硕士，香港大学李嘉诚医学院博士，香港大学、瑞典卡罗琳斯卡医学院博士后。长期专注肿瘤代谢与微环境的研究，相关工作发表于Nature Communications，Hepatology, Cell Reports Medicine 等学术期刊，主持国家级、省级研究基金。
专业擅长
肿瘤代谢重编程与微环境
研究方向
围绕肝癌缺氧微环境驱动代谢适应及治疗耐受的调控机制，重点研究肿瘤细胞营养获取、氧感知、代谢稳态及治疗耐受等关键过程，探索肝癌代谢脆弱性及新的治疗干预策略。
成果奖项：（近五年主要成果及奖励情况）
1. Zhang MS*#, Kwan KKL*, Tse AP, Wang G, Wei LL, Sun K, Chui NN, Lee D, Bao MHR, Pang X, Wu Z, Chen Y, Wang Y, Yang Z, Jiang X, Li Q, Zhang Y, Zhong Y, Cheu JWS, Chen Y, Li W, Wong CM, Wang J, Cai Z, Zhang Q, Liang T, Ng IO, Papathanassiu AE, Wong CC#. BCAT1-dependent HIF-1α stabilization is a targetable metabolic vulnerability in hepatocellular carcinoma. Cell Reports Medicine, 2026, 7(5). doi:10.1016/j.xcrm.2026.102784 (*equal contribution, # Correspondence)
2. Zhang MS, Cui JD, Lee D, Yuen VW, Chiu DK, Goh CC, Cheu JW, Tse AP, Bao MH, Wong BP, Chen Y, Wong CM, Ng IO, Wong CC. Hypoxia-induced macropinocytosis represents a metabolic route for liver cancer. Nature Communications, 2022, 13(1): 954. doi:10.1038/s41467-022-28618-9.
3. Lee D*, Zhang MS*, Tsang FH, Bao MH, Xu IM, Lai RK, Chiu DK, Tse AP, Law DC, Chan CY, Yuen VW, Ng IO Wong CM, Wong CC. Adaptive and Constitutive Activations of Malate Enzyme Family Confer Hepatocellular Carcinoma Multi-layered Protection against Oxidative Stress. Hepatology. 2021 Aug;74(2):776-796. doi: 10.1002/hep.31761. (* equal contribution)
