科 室:骨科

性 别:

最高学历、学位:博士

职 称:教授/主任医师/博导

院内职务:支部书记/科室副主任

出诊信息

注:出诊时间如有变化,以当日挂号为准
门诊时间 门诊地点
星期 一 (上午) 庆春院区
星期 三 (上午) 庆春院区
星期 五 (上午) 庆春院区
星期 二 (上午) 总部一期

个人简介

王跃,教授,主任医师,博士生导师,骨科副主任,浙一脊柱外科学术带头人。2012年获加拿大阿尔伯塔大学博士学位,曾在加拿大皇家亚历山大医院、香港大学玛丽医院、北大三院等世界知名医院脊柱外科学习交流。主攻脊柱外科,擅长各类退行性脊柱疾患的诊治,尤其是脊柱畸形矫正和脊柱微创手术。

以第一作者/通讯作者在国际主流SCI期刊发表论文56篇;主持国家级、省部级和校级各类科研项目20余项;在国际脊柱学术会议作报告20余次,参编《The Intervertebral Disc》等中英文著作6部,申请专利8项。科研成果获国际腰椎学会奖ISSLS奖、中华骨科学会基础研究奖、省自然科学奖、省医药卫生科技奖等多个奖项。现任AOSpine及国际腰椎学会(ISSLS)会员,以及多个国际脊柱杂志审稿人。


专业擅长

擅长颈椎病和腰腿痛的诊治、退行性脊柱疾患的微创治疗、以及脊柱侧弯与脊柱后凸等脊柱畸形矫正手术。


研究方向

专攻脊柱退行性疾患的流行病学、影像学和椎间盘生物学修复研究。

1. 腰椎间盘突出症的生物学修复研究;

2. 腰椎间盘突出症的分子亚型和临床预后研究;

3. 腰腿痛的神经生物学分子机制研究;

4. 腰椎影像学和临床流行病学研究 ;


成果奖项:(近五年主要成果及奖励情况)

一、近五年学术论文

1. Lu X, Chen LH, Jiang C, Cao KL, Gao ZH, Wang Y*. Microglia and macrophages contribute to the development and maintenance of sciatica in lumbar disc herniation. Pain, Accepted.

2. Jin J, Liu Y, Jiang C, Shen Y, Chu G, Liu C, Jiang L, Huang G, Qin Y, Zhang Y, Zhang C, Wang Y*. Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses. Mater Today Bio. 2022 Jul 19;16:100370. doi: 10.1016/j.mtbio.2022.100370. eCollection 2022 Dec. PMID: 35937573 

3. Cheng L, Feng Z, Jon TG, Chen Z, Wang Y*. Remove the infected interbody cage using endoscopy in lumbar spine revision surgery: A case series and technique report. J Orthop Sci. 2022 Jul 20:S0949-2658(22)00181-6. doi: 10.1016/j.jos.2022.06.014. PMID: 35871062

4. Guan M, Chu G, Jin J, Liu C, Cheng L, Guo Y, Deng Z,  Wang Y*. A Combined Cyanine/Carbomer Gel Enhanced Photodynamic Antimicrobial Activity and Wound Healing. Nanomaterials (Basel). 2022 Jun 24;12(13):2173. doi: 10.3390/nano12132173. PMID: 35808008

5. Zhang C, Cai YZ, Wang Y*. Injection of Leukocyte-Poor Platelet-Rich Plasma for Moderate-to-Large Rotator Cuff Tears Does Not Improve Clinical Outcomes but Reduces Retear Rates and Fatty Infiltration: A Prospective, Single-Blinded Randomized Study. Arthroscopy. 2022 Mar 3:S0749-8063(22)00093-7. doi: 10.1016/j.arthro.2022.02.007. PMID: 35247512

6. Du X, Zhang Q, Wang S, Chen X, Wang Y*. MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration. J Clin Lab Anal. 2021 Dec 27:e24214. doi: 10.1002/jcla.24214. PMID: 34961985

7. Lu X, Zhu ZW, Pan JJ, Feng ZY, Lv XQ, Battié MC, Wang Y*. Traumatic vertebra and endplate fractures promote adjacent disc degeneration: evidence from a clinical MR follow-up study. Skeletal Radiol. 2021 Oct 2. doi: 10.1007/s00256-021-03846-0 PMID: 34599674

8. Jiang L, Lin J, Zhao S, Wu J, Jin Y, Yu L, Wu N, Wu Z, Wang Y* Lin M. ADAMTS5 in osteoarthritis: biological functions, regulatory network, and potential targeting therapies. Front Mol Biosci. 2021 Aug 9;8:703110. doi: 10.3389/fmolb.2021.703110. eCollection 2021. PMID: 34434966 

9. Gao Z, Yang Y, Feng Z, Li X, Min C, Zhu Z, Song H, Hu Y, Wang Y*, He X. Chemogenetic stimulation of proprioceptors remodels lumbar interneuron excitability and promotes motor recovery after spinal cord injury. Mol Ther. 2021 Apr 22:S1525-0016(21)00211-2. doi: 10.1016/j.ymthe.2021.04.023. (IF=11.5)

10. Zheng QQ, Shen HT, Tong ZR, Cheng LX, Xu YZ, Feng ZY, Liao SY, Hu XJ, Pang ZY*, Mao ZW*, Wang Y*. A thermosensitive, ROS-responsive, MR409-encapsulated hydrogel ameliorates disc degeneration through inhibiting the secretory autophagy pathway. Theranostics, 2021 Jan 1;11(1):147-163. doi: 10.7150/thno.47723. eCollection 2021. PMID: 33391467 (IF=11.2)

11. Shen HT, Huang JW, Zheng QQ, Zhu ZW, Lv XQ, liu Y*, and Wang Y*. A deep learning based fully automated program to segment and quantify major spinal components on axial lumbar spine MR images. Physical Therapy, 2021 Jun 1;101:1-9. doi: 10.1093/ptj/pzab041. PMID: 33517461

12. Feng ZY, Hu XJ, Zheng QQ, Battié MC, Chen Z, Wang Y*. Cartilaginous endplate avulsion is associated with Modic changes and endplate defects, and residual back and leg pain following lumbar discectomy. Osteoarthritis and Cartilage, 2021 May;29(5):707-717. doi: 10.1016/j.joca.2021.01.010. Epub 2021 Feb 18.

13. Hu XJ, Feng ZY, Huang JW, Zheng QQ, Shen HT, Chen Z, Wang Y*. New MR-based measures for the evaluation of age-related lumbar paraspinal muscle degeneration. European Spine Journal, 2021 Sep;30(9):2577-2585. doi: 10.1007/s00586-021-06811-6. PMID: 33740145

14. Zheng QQ, Hu XJ, Zhang YZ, and Wang Y*. Lumbar disc herniation in a pregnant woman treated with full-endoscopic interlaminar discectomy without X-ray exposure: a case report. Journal of Orthopaedic Science. 2021 Feb 11:S0949-2658(20)30336-5. doi: 10.1016/j.jos.2020.10.021. PMID: 33581926

15. Ding S, Lu X, Liu Z*, Wang Y*. Reduce the fractured central endplate in thoracolumbar fractures using percutaneous pedicle screws and instrumentational maneuvers: Technical strategy and radiological outcomes. Injury. 2021 Apr;52(4):1060-1064.  doi: 10.1016/j.injury.2020.10.014. PMID: 33066988

16. Luo J*, Dolan P, Adams MA, Annesley-Williams DJ, Wang Y*. A predictive model for creep deformation following vertebral compression fractures. Bone. 2020 Aug 16:115595. doi: 10.1016/j.bone.2020.115595. PMID: 32814126

17. Zhang C, Cai YZ*, Lin XJ, Wang Y*. Magnetically Actuated Manipulation and Its Applications for Cartilage Defects: Characteristics and Advanced Therapeutic Strategies. Front Cell Dev Biol. 2020 Jun 30;8:526. doi: 10.3389/fcell.2020.00526. eCollection 2020. PMID: 32695782

18. Maheswaran A, Aiyer SN, Farouk O, El-Sharkawi M, Park JB, O'Brien A, Oluwole I, Wang Y, Arruda AO, Rajasekaran S. Assessment of Interobserver Variability for CT Scan-Based Evaluation of Posterior Ligament Complex Injury in Thoracolumbar Fractures: An International Multicenter Pilot Study. Global Spine J. 2020 Apr;10(2):118-129. PMID: 32206510

19. Lu X, Yang J, Zhu Z, Lv X, Wu J, Huang J, Yu L, Wen Z, Luo J, Wang Y*. Changes of the adjacent discs and vertebrae in patients with osteoporotic vertebral compression fractures treated with or without bone cement augmentation. Spine J. 2020 Jul;20(7):1048-1055. doi: 10.1016/j.spinee.2020.02.012. PMID: 32105771

20. Huang JW, Shen HT, Liu Yong, Wang Y*, Spine Explorer: a deep learning based fully automated program for efficient and reliable quantifications of the vertebrae and discs on sagittal lumbar spine MR images. Spine J. 2020 Apr;20(4):590-599. doi: 10.1016/j.spinee.2019.11.010. PMID: 31759132

21. Chen LH, Battié MC, Yang G, Yuan Y, Chen Z, Wang Y*, Lumbar vertebral endplate defects on magnetic resonance images: prevalence, distribution patterns, and associations with back pain in a population-based sample of Chinese. Spine J. 2020 Mar;20(3):352-360. doi: 10.1016/j.spinee.2019.10.015. PMID:31669615

22. Wu K, Zhao Y, Feng Z, Hu X, Chen Z, Wang Y*. Stepwise local anesthesia for percutaneous endoscopic interlaminar discectomy: technique strategy and clinical outcomes. World Neurosurg. 2020 Feb;134:e346-e352. doi: 10.1016/j.wneu.2019.10.061. PMID: 31634623

23. Wu J, Huang J, Battié MC, Wang Y*. Lifestyle and lifetime occupational exposures may not play a role in the pathogenesis of Modic changes on the lumbar spine MR images. Spine J. 2020 Jan;20(1):94-100. doi: 10.1016/j.spinee.2019.08.009. Epub 2019 Aug 20.

24. Chen Y, Yang H, Wang Y, Zou J. Relationship of endplate changes and low back pain after discectomy. Clin Neurol Neurosurg. 2019 Sep;184:105449. doi: 10.1016/j.clineuro.2019.105449. Epub 2019 Jul 18. PMID: 31344509 

25. Chen Y, Yang H, Zhang L, Wang Y, Zou J. Analyzing the Influence of Modic Changes on Patients with Lower Back Pain Undergoing Conservative Treatment. Pain Res Manag. 2019 Mar 19;2019:8185316. doi: 10.1155/2019/8185316. eCollection 2019.

26. Yang G, Chen L, Gao Z*, Wang Y*. Implication of microglia activation and CSF-1/CSF-1R pathway in lumbar disc degeneration-related back pain. Mol Pain. 2018 Jan-Dec;14:1744806918811238. doi: 10.1177/1744806918811238. PMID: 30326776 

27. Hu XJ, Chen LH, Battié MC, Wang Y*. Methodology and Cohort Profile for the Hangzhou Lumbar Spine Study: A Population-based Study Focusing on Back Health in Chinese. J Zhejiang Univ Sci B. 2018 Jul;19(7):547-558. doi: 10.1631/jzus.B1700484. PMID: 29971993

28. Hu XJ, Chen MJ, Pan J, Liang L, Wang Y*. Is it appropriate to measure lumbar disc degeneration on the middle sagittal MR image? A quantitative image study. Eur Spine J. 2018 May;27(5):1073-1081. doi: 10.1007/s00586-017-5357-3. PMID: 29147797

29. Chen LH, Hu XJ, Battié MC, Wang Y* (2018) Modic Changes in the lumbar spine are common aging related degenerative findings that parallel with disc degeneration, Clinical Spine Surgery, 2018 Aug;31(7):312-317 doi: 10.1097/BSD.0000000000000662 PMID: 29847414

30. Chen L, Chen Z, Wang Y*. Langerhans cell histiocytosis at L5 vertebra treated with en bloc vertebral resection: a case report. World J Surg Oncol. 2018 May 22;16(1):96. doi: 10.1186/s12957-018-1399-1. PMID: 29788958

31. Lv X, Lu X, Wang Y*. Entrapment of a metal foreign body in the cervical spinal canal during surgical procedure: A case report. Medicine (Baltimore). 2018 Apr;97(17):e0548. doi: 10.1097/MD.0000000000010548. PMID: 29703036

32. Hu XJ, Chen Z, Wang Y*. A rare case of concomitant cervical disc herniation and intradural meningioma treated with one-stage posterior surgery. European Spine Journal, 2017 Dec 14. doi: 10.1007/s00586-017-5414-y

33. O'Callaghan P, Szarko M, Wang Y*, Luo J*. Effects of bone damage on creep behaviours of human vertebral trabeculae. Bone. 2017 Nov 3;106:204-210. doi: 10.1016/j.bone.2017.10.022

34. Feng Z, Liu Y, Yang G, Battié MC, Wang Y*. Lumbar Vertebral Endplate Defects on Magnetic Resonance Images: Classification, Distribution Patterns, and Associations with Modic Changes and Disc Degeneration. Spine (Phila Pa 1976). 2018 Jul 1;43(13):919-927. doi: 10.1097/BRS.0000000000002450. PMID: 29019806

35. Pan J, Lu X, Yang G, Han Y, Tong X, Wang Y*. Lumbar disc degeneration was not related to spine and hip bone mineral densities in Chinese: facet joint osteoarthritis may confound the association. Arch Osteoporos. 2017 Dec;12(1):20. doi: 10.1007/s11657-017-0315-6. PMID: 28210985

36. Yang G, Battié MC, Boyd SK, Videman T, Wang Y*. Cranio-caudal asymmetries in trabecular architecture reflect vertebral fracture patterns. Bone. 2017 Feb;95:102-107. doi: 10.1016/j.bone.2016.11.018. PMID: 27876503 (IF=3.71)

37. Feng ZY#, Chen LH#, Hu XJ, Yang G, Wang Y*, Chen Z (2017), Vertebral augmentation can induce early signs of degeneration in the adjacent intervertebral disc: evidence from a rabbit model. Spine. 2018 Oct 15;43(20):E1195-E1203. doi: 10.1097/BRS.0000000000002666. PMID: 29649084

38. Feng ZY, Liu YH, Wei W, Hu S, Wang Y*. Type II Modic Changes may not always represent fat degeneration:A study using MR fat suppression sequence. Spine (Phila Pa 1976). 2016 Aug 15;41(16):E987-94. doi: 10.1097/BRS.0000000000001526. PMID: 26909837 (IF=2.297)

 

二、近五年专利成果

1. 王跃 一种基于横断位磁共振图像的腰椎肌肉测量方法,发明专利,ZL2020114954561

2. 王跃,陆轩。一种腰椎间盘突出症动物模型的构建方法

3. 王跃,黄嘉炜。一种基于核磁共振图像的腰椎椎体量化测量方法

4. 王跃,陆轩。一种用于椎间孔入路经皮内镜腰椎间盘切除术的体表定位装置

5. 王跃,胡小坚。一种用于获取脊柱椎体-终板-椎间盘复合体标本的器械组件

6. 王跃,梁亮。腰椎磁共振图像半自动量化测量软件(Spine Explorer V1.0),计算机软件著作权,2018SR946995

7. 王跃,黄彦成,袁颖。脊柱疾病病案在线收集系统软件(Spine Manager 1.0), 计算机软件著作权,2018SR144404

8. 王跃,一种颈椎前路手术用充气式颈椎体位调节装置,新型实用专利,ZL201520866994.5

 

三、获得荣誉

1. 2018年8月,浙江省科学技术厅, 自然科学三等奖 (椎体和终板在腰椎间盘退变和腰痛中的病理作用及机制研究),排名第一;

2. 2018年4月,浙江省医药卫生科技奖二等奖(腰椎椎体和终板在腰椎退行性疾病中的病理作用和临床流行病学研究),排名第一;

3. 2017年11月,中国医药教育协会科技创新二等奖(腰椎间盘退行性疾病发病机制新发现及其治疗过程中的意义),排名第二;

4. 2016年10月,中华骨科学会(COA)骨科基础青年研究二等奖,排名第一;

5. 2016年度,浙江大学医学院“优秀班主任”;

6. 2016 AOSpine Fellowship

7. 2014年9月,香港大学李嘉诚医学院郑裕彤博士(Dr. Cheng Yu Tung)奖学金;

8. 2014 AOSpine Fellowship

9. 2012年5月,国际腰椎学会(ISSLS),ISSLSPrize(脊柱研究最高国际学术荣誉),15,000 USD, 排名第一;


社会任职

  • 国际腰椎协会(ISSLS)会员

  • AOSpine会员

  • 国际微创脊柱外科学会年会(ISMISS)青年委员

  • 中国医师协会浙江省分会神经修复协会副主任委员

  • 中国研究型医院学会颈椎疾病健康管理与加速康复专业委员会委员

  • 浙江省抗癌协会第七届骨与软组织肿瘤专业委员会副主任委员

  • 浙江省康复医学委员会脊柱脊髓损伤委员会委员

  • 浙江省医学会骨科分会青年委员、骨病组副组长

  • 浙江省中西结合骨伤医学会委员

  • 中国医促会结合骨伤医学会青年委员

  • 中国医促会脊柱内镜分会委员

  • 中华医学会结核病学分会骨结核专业委员会委员

  • Spine、European Spine Journal 审稿人