科 室:麻醉科

性 别:

最高学历、学位:硕士

职 称:主任医师、硕士生导师

院内职务:麻醉科副主任

出诊信息

注:出诊时间如有变化,以当日挂号为准
门诊时间 门诊地点

个人简介

1987年毕业于浙江医科大学医疗系,先后获学士硕士学位。于1993年7月赴美国西弗吉尼亚大学医学院访问学者。为浙江省医学创新学科(小儿麻醉学)带头人。


专业擅长

从事临床麻醉一线工作30余年,临床经验丰富,擅长小儿麻醉和危重疑难患者的抢救及处理等。



研究方向

围手术期重要脏器保护,全身麻醉药对发育中大脑的神经毒性



成果奖项:(近五年主要成果及奖励情况)

一、发表文章

1.Linghua Xie, Yuhan Hu, Dandan Yan, P. McQuillan, Yue Liu, Shengmei Zhu, Zhirui Zhu, Yilei Jiang, Zhiyong Hu*(通讯作者). The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder , Pharmacological Research,2021;165:105440.(IF 7.658) 

2.Linghua Xie, Yue Liu, Yuhan Hu, Bei Wang, Zhirui Zhu, Yilei Jiang, Yaojun Suo, Miaofeng Hu, Jing Gao, Rahim Ullah, Zhiyong Hu*(通讯作者). Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice. Translational Psychiatry, 2020;10(1):202. (IF 6.22)

3.L. Xu, Y. Hu, L. Huang, Y. Liu, B. Wang, L. Xie, Z. Hu*(通讯作者). The association between attention deficit hyperactivity disorder and general anaesthesia - a narrative review. Anaesthesia, 2019;74:57-63. (IF 5.879)

4.Jing Gao, Hongfu Yu, Xuehong Bai, Chang Liu, Lin Chen, Karine Belguise, Xiaobo Wang, Kaizhi Lu*, Zhiyong Hu*(共同通讯作者), Bin Yi*. Loss of cell polarity regulated by PTEN/Cdc42 enrolled in the process of Hepatopulmonary Syndrome. J Cell Mol Med. 2019;23:5542-5552. (IF 4.658) DOI: 10.1111/jcmm.14437

5.Lili Xu, Jianjun Shen, Jianliang Sun, Patrick M. McQuillan, Zhiyong Hu*(通讯作者). The Effects of Leukocyte Filtration on Cell Salvaged Autologous Blood Transfusion on Lung Function and Lung Inflammatory and Oxidative Stress Reactions in Elderly Patients Undergoing Lumbar Spinal Surgery. J Neurosurg Anesthesiol, 2019;31(1):36-42. (IF 4.026)

6.Weidi Ye, Yuhan Hu, Yuntao Wu, Zhirui Zhu, Xiuming Jin, Zhiyong Hu*(通讯作者). Retrobulbar dexmedetomidine in pediatric vitreoretinal surgery eliminates the need for intraoperative fentanyl and postoperative analgesia: A randomized controlled study. Indian J Ophthalmol, 2019;67:922-7.(IF 0.977)

7.Lili Xu, Jianjun Shen, Patrick M. McQuillan, Zhiyong Hu*(通讯作者). Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don’t. Curr Med Chem, 2018;25(8):908-916. (IF 3.469)

8.Lili Xu, Zhiyong Hu*(通讯作者), Jianjun Shen, Patrick M. McQuillan. Efficacy of US-guided transversus abdominis plane block and rectus sheath block with ropivacaine and dexmedetomidine in elderly high-risk patients. Minerva Anestesiol, 2018;84(1):18-24. (IF 2.693)

9.Lili Xu, Jianjun Shen, Lina Yu, Jianliang Sun, Patrick M. McQuillan, Zhiyong Hu, Min Yan*.  Role of autophagy in sevoflurane-induced neurotoxicity in neonatal rat hippocampal cells. Brain Research Bulletin, 2018,140:291-298

10.Jialian Zhao,  Qiang Gu,  Lifeng Wang, Weize Xu, Lihua Chu, Ya Wang, Zhongwang Li, Shuijing Wu, Jianguo Xu, Zhiyong Hu, Qiang Shu*, Xiangming Fang*. Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients. Mediators of Inflammation, 2018;5:2152650,

11.Ruifeng Zeng, Xiulan Liu, Jing Zhang, Ning Yin, Jian Fei, Shan Zhong,  Zhiyong Hu, Miaofeng Hu, Mazhong Zhang, Bo Li, Jun Li,  Qingquan Lian,Wangning ShangGuan*. The efficacy and safety of mivacurium in pediatric patients. BMC Anesthesiology, 2017;17:58

12.Zhiyong Hu*(通讯作者), Lili Xu, Zhirui Zhu, Robert Seal, Patrick M. McQuillan. Effects of hypothermic cardiopulmonary bypass on internal jugular bulb venous oxygen saturation, cerebral oxygen saturation, and bispectral index in pediatric patients undergoing cardiac surgery: A prospective study. Medicine, 2016;95(2):e2483.

13.Lili Xu, Zhiyong Hu*(通讯作者), Jianjun Shen, Patrick M. McQuillan. Effects of Ginkgo biloba extract on cerebral oxygen and glucose               metabolism in elderly patients with cerebral ischemia. Complement Ther Med, 2015;23(2):220-225.

14.Weidi Ye, Zhiyong Hu*(通讯作者), Xiuming Jin. Retrobulbar dexmedetomidine decreases the MLAC of ropivacaine in vitreoretinal     surgery in children. Eur J Ophthalmol, 2015;25(4):352-356.

15.Weidi Ye, Zhiyong Hu*(通讯作者), Xiuming Jin, Pei Wang. Effects of dexmedetomidine for retrobulbar anesthesia in orbital ball implants after enucleation surgery. Indian J Ophthalmol, 2015;63(9):704-9.

16.Lili Xu, Zhiyong Hu*(通讯作者), Jianjun Shen, Patrick M McQuillan. Does dexmedetomidine have a cardiac protective effect during non-cardiac surgery? A randomised controlled trial. Clin Exp Pharmacol Physiol, 2014;41(12):879-883.

17.Zhirui Zhu, Zhiyong Hu*(通讯作者), Yilei Jiang, Lili Xu, Patrick M. McQuillan. The use of a double-lumen central venous catheter for airway management in pediatric patients undergoing laryngeal papillomatosis surgery. Pediatric Anesthesia,2014;24(2):157-163.

18.Zhirui Zhu, Zhiyong Hu*(通讯作者), Sufeng Lin. Response to Dr Sen et al: Pediatric airway surgery under spontaneous breathing. Pediatric Anesthesia (letter), 2014;24(11):1195-6

19.Xu Lili, Hu Zhiyong* (通讯作者), Shen Jianjun. A Comparison of the GlideScope With the Macintosh Laryngoscope for Nasotracheal Intubation in Patients With Ankylosing Spondylitis. J Neurosurg Anesthesiol, 2014;26(1):27-31.

20.Zhi-yong Hu*(通讯作者), Hai-yan Jin, Li-li Xu, Zhi-rui Zhu, Yi-lei Jiang, Robert Seal. Effects of sevoflurane on the expression of tau protein mRNA and Ser396/404 site in the hippocampus of developing rat brain. Pediatric Anesthesia,2013;23(12):1138-1144.

21.Haiyan Jin, Zhiyong Hu* (通讯作者), Mengjie Dong, Yidong Wu, Zhirui Zhu, Lili Xu. Ketamine induced tau hyperphosphorilation at Serine 404 in the hippocampus of neonatal rats. Neural Regen Res, 2013;17(8):1590-1596.

22.Xu Lili, Hu Zhiyong*(通讯作者), Shen  Jianjun. A  preliminary  study of  the  effects  of  ulinastatin  on  early  postoperative  cognition function  in  patients  undergoing  abdominal  surgery. Neuroscience Lett, 2013;541(4):15-19.

23.Xu Lili, Hu Zhiyong*(通讯作者), Shen Jianjun. Asleep awake asleep technique in children during strabismus surgery under sufentanil balanced anesthesia. Pediatric Anesthesia, 2012;22(12):1216-1220


二、主持国家自然科学基金

1.七氟醚暴露经星形胶质细胞GABABR-TSP1诱发ADHD样行为的机制研究 国家自然科学基金 面上项目 82171260(负责人)2022.01-2025.12, 

2.七氟醚暴露经NMDAR-GSK3-Tau通路影响发育中大脑突触可塑性的研究 国家自然科学基金 面上项目 81471240(负责人)2015.01-2018.12,

3. BDNF调控七氟醚诱导发育中鼠社交行为异常的机制研究 国家自然科学基金 应急管理项目 81641042(负责人)2017.01-2017.12。


三、专利

1.胡智勇 胡妙凤, 左房肺动脉中心静脉联合测压导管, 2018.03.27, 中国, ZL2017 2 0246622.1 

2.胡智勇, 喉麻和呼末二氧化碳采样导管,2019.03.19,中国,ZL 2017 2 0944680.1


四、指南及专家共识制定

1.儿童加速康复外科麻醉中国专家共识(执笔人),中华医学杂志, 2021;101(31):2425-2430.

2.小儿日间手术麻醉指南(执笔人),中华医学杂志, 2019,99(8):566-570.

3.基于快速康复的小儿外科围手术期气道管理专家共识(参编),中华小儿外科杂志, 2019,40(7):577-582.

4.小儿吸入麻醉诱导专家指导意见(参编),中华麻醉在线,2017-12-14.

5.新生儿和低体重新生儿麻醉指南(参编),2017


五、获奖

获浙江省科技进步三等奖1项:全身麻醉对婴儿认知行为及脑功能的影响(排名第一), 2020.7


六、出版物编写

1. 小儿麻醉知多少 (主编)人民卫生出版社 2015   

2. 小儿麻醉手册(第二版)(副主编)上海世界图书出版公司 2017

3. 临床麻醉学病例解析 (编委) 人民卫生出版社 2018.10

4. 小儿麻醉临床案例手册 (编委)人民卫生出版社 2016.12


社会任职

中华医学会麻醉学分会儿科麻醉学组委员兼学术秘书

中国心胸血管麻醉学会日间手术麻醉分会副主任委员

浙江省医学会麻醉学分会副主任委员

浙江省神经科学学会麻醉学专业委员会副主任委员