个人简介

教授，博士生导师。浙大医学院附属第一医院余杭院区副院长，病理科主任了，中国健康和疾病人脑组织库主任。曾任华盛顿大学医学院神经病理科主任、北京大学基础医学院病理系/北医三院病理科主任。担任许多世界级神经科学杂志，如American Journal of Pathology，Brain Pathology，Neurological Disease，Neurochemical Res等的编委，并担任Science，Nature 和PNAS等众多国际知名科学杂志的审稿人。同时，还常年作为美国NIH 基金评委，也连续多年作为中国国家自然科学基金二审评委。2017年6月，代表中国病理学界成功地获得了2019年亚太国际病理大会在中国举办权。在国际神经病理学术界享有极高声誉。发表文章约250篇SCI文章，其中包括世界顶级杂志，如Lancet Neurology，Acta Neuropathologica，Science Translational Medicine，Alzheimers & Dementia等，总引用次数超过17,000次，h-指数71，i10-指数199。

专业擅长

神经病理 （神经肿瘤及神经退行性疾病）。团队在神经退行性疾病早期诊断生物标志物研究与转化应用领域处于国际领先地位，尤其是在外周体液分离和鉴定中枢神经系统来源生物标志物领域，更是处于行业引领地位，拥有多项国际/国内专利技术。在阿尔茨海默病（Alzheimer’s disease，AD）和帕金森病（Parkinson’s disease，PD）的早期诊断生物标志物研究方面，章京教授发表的文章在数量和质量上均处于国际同行的第一阵列。

研究方向

神经退行性疾病早期诊断生物标志物研究与转化应用，从外周体液中分离和鉴定中枢神经系统疾病生物标志物新技术研发等。

成果奖项：（近五年主要成果及奖励情况）

1. Zhenwei Yu #, Min Shi#, Tessandra Stewart, Pierre-Olivier Fernagu, Yang Huang, Chen Tian, Benjamin Dehay, Anzari Atik, Dishun Yang, Francesca De Giorgi, François Ichas, Marie-Hélène Canron, Roberto Ceravolo, Daniela Frosini, Han-Joon Kim, Tao Feng, Wassilios G Meissner*, Jing Zhang*. Reduced oligodendrocyte exosome secretion in multiple system atrophy involves SNARE dysfunction[J]. Brain, 2020.2.23 Received, will online in 2020.June.SCI

2. Li N#, Wu Y, Zhu L, Huang Y, Liu Z, Shi M, Soltys D, Zhang J*, Chang Q* Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP.[J]. Biochem Biophys Res Commun. 2019 Oct 1;517(4):642-647. SCI

3. Chen Tian#, Genliang Liu, Liyan Gao, David Soltys, Catherine Pan, Tessandra Stewart, Min Shi, Zhiying Xie, Na Liu, Tao Feng *, Jing Zhang *.Erythrocytic α-Synuclein as a potential biomarker for Parkinson’s disease[J]. Translational Neurodegeneration, 2019, 8(1). SCI

4. Yong‐Xiao Li#, Zhen‐Wei Yu#, Tao Jiang, Li‐Wei Shao, Yan Liu, Na Li, Yu‐Feng Wu, Chen Zheng, Xiao‐Yu Wu, Ming Zhang, Dan‐Feng Zheng, Xue‐Ling Qi, Min Ding, Jing Zhang*, Qing Chang*.SNCA, a novel biomarker for Group 4 medulloblastomas, can inhibit tumor invasion and induce apoptosis. Cancer science. 2018,109(4) :1263-1275.SCI

5. Hua Wang#, Tessandra Stewart, Jon B Toledo, Carmen Ginghina, Lu Tang, Anzari Atik, Patrick Aro, Leslie M Shaw, John Q Trojanowski, Douglas R Galasko, Steven Edland, Poul H Jensen, Min Shi, Jing Zhang*.A Longitudinal Study of Total and Phosphorylated α-Synuclein with Other Biomarkers in Cerebrospinal Fluid of Alzheimer’s Disease and Mild Cognitive Impairment. Journal of Alzheimer's Disease. 2018,61(4):1541-1553.SCI

6. Zhenwei Yu#, Tessandra Stewart, Jan Aasly, Min Shi, Jing Zhang*.Combining clinical and biofluid markers for early Parkinson's disease detection. Annals of clinical and translational neurology. 2018,5(1):109-114.SCI

7. Hua Wang#, Anzari Atik, Tessandra Stewart, Carmen Ginghina, Patrick Aro, Kathleen F Kerr, John Seibyl, Danna Jennings, Poul Henning Jensen, Kenneth Marek, Min Shi, Jing Zhang*.Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study. Neurobiology of disease. 2018,116:53-59.SCI

8. Min Shi#, Lu Tang#, Jon B Toledo, Carmen Ginghina, Hua Wang, Patrick Aro, Poul H Jensen, Daniel Weintraub, Alice S Chen-Plotkin, David J Irwin, Murray Grossman, Leo McCluskey, Lauren B Elman, David A Wolk, Edward B Lee, Leslie M Shaw, John Q Trojanowski, Jing Zhang*.Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia. 2018,14(8):1052-1062.SCI

9. William A Banks#, Andrej Kovac, Petra Majerova, Kristin M Bullock, Min Shi, Jing Zhang*.Tau Proteins Cross the Blood-Brain Barrier. Journal of Alzheimer's Disease. 2017,55(1):411-419.SCI

10. Junichi Matsumoto#, Tessandra Stewart, William A Banks, Jing Zhang*.The transport mechanism of extracellular vesicles at the blood-brain barrier. Current pharmaceutical design. 2017,23(40):6206-6214.SCI

11. Ingrid Chang, Gordana Juric-Sekhar, Desiree Marshall, Jing Zhang*.An incidental finding of choroidal ganglioneuronal hamartoma in a patient with neurofibromatosis type 1. Ophthalmic plastic and reconstructive surgery. 2017,33(3):S40-S42.SCI

12. Min Shi#, Andrej Kovac, Ane Korff, Travis J Cook, Carmen Ginghina, Kristin M Bullock, Li Yang, Tessandra Stewart, Danfeng Zheng, Patrick Aro, Anzari Atik, Kathleen F Kerr, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Thomas J Montine, William Banks, Jing Zhang*.CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimer's & dementia: the journal of the Alzheimer's Association. 2016,12(11):1125-1131.SCI

13. Shijun Wang#, Chun-Hsien Chu, Mingri Guo, Lulu Jiang, Hui Nie, Wei Zhang, Belinda Wilson, Li Yang, Tessandra Stewart, Jau-Shyong Hong, Jing Zhang*.Identification of a specific α-synuclein peptide (α-Syn 29-40) capable of eliciting microglial superoxide production to damage dopaminergic neurons. Journal of neuroinflammation. 2016,13(1):158.SCI

14. Xiangmin Lin#, Min Shi, Jeyaraj Gunasingh Masilamoni, Romel Dator, James Movius, Patrick Aro, Yoland Smith, Jing Zhang*.Proteomic profiling in MPTP monkey model for early Parkinson disease biomarker discovery. Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics. 2015,1854(7):779-787.SCI

15. Shijun Wang#, Chun-Hsien Chu, Tessandra Stewart, Carmen Ginghina, Yifei Wang, Hui Nie, Mingri Guo, Belinda Wilson, Jau-Shyong Hong, Jing Zhang*.α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation. Proceedings of the National Academy of Sciences. 2015,112(15):E1926-E1935.SCI

16. Min Shi#, James Movius, Romel Dator, Patrick Aro, Yanchun Zhao, Catherine Pan, Xiangmin Lin, Theo K Bammler, Tessandra Stewart, Cyrus P Zabetian, Elaine R Peskind, Shu-Ching Hu, Joseph F Quinn, Douglas R Galasko, Jing Zhang*.Cerebrospinal fluid peptides as potential Parkinson disease biomarkers: a staged pipeline for discovery and validation. Molecular & Cellular Proteomics. 2015,14(3):544-555.SCI

17. Tianfang Jiang#, Jake Hoekstra, Xin Heng, Wenyan Kang, Jianqing Ding, Jun Liu, Shengdi Chen, Jing Zhang*.P2X7 receptor is critical in α-synuclein–mediated microglial NADPH oxidase activation. Neurobiology of aging. 2015,36(7):2304-2318.SCI

18. Ge Li#, Kangping Xiong, Ane Korff, Catherine Pan, Joseph F Quinn, Douglas R Galasko, Chunfeng Liu, Thomas J Montine, Elaine R Peskind, Jing Zhang*.Increased CSF E-Selectin in Clinical Alzheimer’s Disease without Altered CSF A β 42 and Tau. Journal of Alzheimer's Disease. 2015,47(4):883-887.SCI

19. Changqin Liu#, Brenna Cholerton, Min Shi, Carmen Ginghina, Kevin C Cain, Peggy Auinger, Jing Zhang*.CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's disease. Parkinsonism & related disorders. 2015,21(3):271-276.SCI

20. Catherine Pan#, Ané Korff, Douglas Galasko, Carmen Ginghina, Elaine Peskind, Ge Li, Joseph Quinn, Thomas J Montine, Kevin Cain, Min Shi, Jing Zhang*.Diagnostic Values of Cerebrospinal Fluid T-Tau and Aβ 42 using Meso Scale Discovery Assays for Alzheimer's Disease. Journal of Alzheimer's Disease. 2015,45(3):709-719.SCI

社会任职

世界病理学会中国分会秘书长

中国神经科学学会神经退行性疾病分会副主任委员