科 室:余杭院区泌尿外科

性 别:

最高学历、学位:博士

职 称:副主任医师

出诊信息

注:出诊时间如有变化,以当日挂号为准
门诊时间 门诊地点
星期 六 (上午) 总部一期
星期 四 (上午) 总部一期
星期 六 (下午) 总部一期

个人简介

毕业于浙江大学医学院,获临床医学博士学位,长期从事泌尿外科临床一线工作,擅长泌尿系结石及各类肿瘤的诊断及微创手术治疗;参研国家自然科学基金面上项目1项,青年基金3项;以第一作者身份发表SCI论文5篇(其中IF>5分者3篇),参与发表SCI论文十余篇。


专业擅长

泌尿系结石及泌尿系肿瘤的微创手术,尤其擅长肾脏及前列腺相关疾病的外科治疗。


研究方向

泌尿系肿瘤的早期分子诊断及表观遗传学调控


成果奖项:(近五年主要成果及奖励情况)

主参课题:1.国家自然科学基金青年项目,81502215,靶向增强子的小激活RNA激活前列腺癌细胞E-钙粘蛋白表达的机制初探,2016.01-2018.12。

2.国家自然科学基金青年项目,81702500,c-Met和DLK1-DIO3印记域miRNA簇之间的调控环路在膀胱癌恶性行为中的作用及其机制研究,2018.01-2020.12。

3. 国家自然科学基金面上项目,81874203,METTL3/YTHDF2 m6A轴介导的circ-DNMT3b

的竞争性表达调控及其在膀胱癌顺铂耐药中的机制研究,2019.01-2022.12。

4.国家自然科学基金青年项目,81772744,YTHDF2通过转录后调控m6A修饰的NKX3.1介导AKT/GSK3β通路在前列腺癌中的作用及分子机制研究,2019.01-2022.12。


主要论文(第一作者):

(1)Liang Z, Wang X, Xu X, Xie B, Ji A, Meng S, Li S, Zhu Y, Wu J, Hu Z, Lin Y, Zheng X, Xie L*, Liu B*. MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway. Molecular Cancer.2017, 16(1):96.

(2)Liang Z, Wang X, Xie B, Zhu Y, Wu J, Li S, Meng S, Zheng X, Ji A*, Xie L. Pesticide exposure and risk of bladder cancer: A meta-analysis. Oncotarget. 2016

(3)Wang X#, Liang Z#, Xu X, Li J, Zhu Y, Meng S, Li S, Wang S, Xie B, Ji A, Liu B, Zheng X, Xie L*. miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. Cell Death Dis. 2016 Dec 1; 7(12):e2503.(加#者为共同第一作者)

(4)Liang Z, Xie B, Li J, Wang X, Wang S, Meng S, Ji A, Zhu Y, Xu X, Zheng X, Xie L*. Hypertension and risk of prostate cancer: a systematic review and meta-analysis. Sci Rep. 2016 Aug 11; 6:31358.

(5)Liang Z, Li S, Xu X, Xu X, Wang X, Wu J, Zhu Y, Hu Z, Lin Y, Mao Y, Chen H,Luo J, Liu B, Zheng X, Xie L*. MicroRNA-576-3p inhibits proliferation in bladder cancer cells by targeting cyclin D1. Mol Cells. 2015;38(2):130-7.

参与发表论文:

1)Shu Y, Ren L, Xie B, Liang Z, Chen J*.miR-204 enhances mitochondrial apoptosis in doxorubicin-treated prostate cancer cells by targeting SIRT1/p53 pathway. Oncotarget. 2017 Oct 23;8(57):97313-97322.

(2)  Li J, Xu X, Meng S, Liang Z, Wang X, Xu M, Wang S, Li S, Zhu Y, Xie B, Lin Y, Zheng X, Liu B,Xie L*. MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial-mesenchymal transition progression in bladder cancer. Cell Death Dis. 2017 Aug 24;8(8):e3010.

(3)Xu X, Li J, Wang X, Wang S, Meng S, Zhu Y, Liang Z, Zheng X, Xie L*. Tomato consumption and prostate cancer risk: a systematic review and meta-analysis. Sci Rep. 2016 Nov 14;6:37091

(4) Xu X, Zhu Y, Liang Z, Li S, Xu X, Wang X, Wu J, Hu Z, Meng S, Liu B, Qin J, Xie L*, Zheng X*. c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial-mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling. Cell Death Dis. 2016 Feb 4;7:e2088.

(5)Xie B, Hu Y, Liang Z, Liu B, Zheng X, Xie L*. Association between pesticide exposure and risk of kidney cancer: a meta-analysis. Onco Targets Ther. 2016 Jun 28;9:3893-900.

(6)Li S, Zhu Y, Liang Z, Wang X, Meng S, Xu X, Xu X, Wu J, Ji A, Hu Z, Lin Y, Chen H, Mao Y, Wang W, Zheng X, Liu B, Xie L*. Up-regulation of p16 by miR-877-3p inhibits proliferation of bladder cancer. Oncotarget. 

2016 Jul 13.

(7)Wang X, Ji A, Zhu Y, Liang Z, Wu J, Li S, Meng S, Zheng X, Xie L*. A meta-analysis including dose-response relationship between night shift work and the risk of colorectal cancer. Oncotarget. 2015 Sep 22;6(28):25046-60.

(8) Zhu Y, Wu J, Li S, Wang X, Liang Z, Xu X, Xu X, Hu Z, Lin Y, Chen H, Qin J, Mao Q, Xie L*. Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer. Mol Med Rep. 2015 Feb;11(2):1004-8.

(9)Wang X, Lin YW, Wu J, Zhu Y, Xu XL, Xu X, Liang Z, Hu ZH, Li SQ, Zheng XY, Xie LP*. Meta-analysis of nonsteroidal anti-inflammatory drug intake and prostate cancer risk. World J Surg Oncol. 2014 Oct 5;12:304.

(10) Wang X, Wu J, Lin Y, Zhu Y, Xu X, Xu X, Liang Z, Li S, Hu Z, Zheng X, Xie L*. MicroRNA-320c inhibits tumorous behaviors of bladder cancer by targeting Cyclin-dependent kinase 6. J Exp Clin Cancer Res. 2014 Sep 2;33:69.

(11) Xu X, Wu J, Li S, Hu Z, Xu X, Zhu Y, Liang Z, Wang X, Lin Y, Mao Y, Chen H, Luo J, Liu B, Zheng X, Xie L*. Downregulation of microRNA-182-5p contributes to renal cell carcinoma proliferation via activating the AKT/FOXO3a signaling pathway. Mol Cancer. 2014 May 17;13:109.

(12)Wu J, Ji A, Wang X, Zhu Y, Yu Y, Lin Y, Liu Y, Li S, Liang Z, Xu X, Zheng X, Xie L*. MicroRNA-195-5p, a new regulator of Fra-1, suppresses the migration and invasion of prostate cancer cells. J Transl Med. 2015 Sep 4;13:289.