个人简介
浙江大学转化医学研究院教授，浙江大学王宽诚杰出讲席教授，浙江省引进培育领军型创新创业团队领军人才。原任美国MD安德森癌症中心Ruby E.Rutherford杰出讲席终身教授、肿瘤代谢中心创始主任。吕教授是肿瘤学和细胞信号转导研究领域国际知名的杰出科学家，对肿瘤细胞能量代谢的研究取得了开创性、系统性的重要成果，在国际上首次揭示了多种代谢酶具有蛋白激酶活性，首次系统性地阐明了生长因子受体促进 Warburg 效应的调控机制，率先证实了多种代谢酶和代谢物在肿瘤细胞活动调控中具有重要的非代谢功能。
吕志民教授2013年获得M.D.安德森癌症中心Potu N. Rao基础科学卓越奖、2016年获得M.D.安德森癌症中心Dallas/Fort Worth传奇人物基础研究成就奖、2017年当选美国科学促进会（AAAS）会士。2021年当选欧洲科学院Academia Europaea外籍院士。受邀担任精准医学杂志荣誉主编，Visualized Cancer Medicine 主编，Journal of National Cancer Center副主编， Cell Research、The Journal of Biological Chemistry等10余个期刊的编委。
吕志民教授先后在Nature（4篇）、Cell（2篇）、Nature Cell Biology（5篇）、Molecular Cell（15篇）、Cancer Cell、Cancer Discovery、Cell Metabolism、Nature Reviews Molecular Cell Biology等发表论文100多篇，其中在Cell、Nature、Science系列杂志中发表论文40余篇。其原创性里程碑发现深刻影响了业界对肿瘤代谢的认识，同时也对开拓新的肿瘤诊治方法提供了创新理论支持。
专业擅长
肿瘤代谢
研究方向
肿瘤代谢
成果奖项：（近五年主要成果及奖励情况）
1. Ji H, Lee J, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z*. EGFR phosphorylates FAM129B to promote Ras activation. PNAS. 1/2016. 113(3):644-9. PMID:26721396.
2. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke D, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, and Lu Z*. Mitochondria-translocated phosphoglycerate kinase 1 functions as a protein kinase to coordinate glycolysis and TCA cycle in tumorigenesis. Molecular Cell. 3/2016. 61(5):705-719. PMID:26942675. (highlighted by MD Anderson news release).
3. Li X, Qian X, Peng L, Jiang Y, Hawke D, Zheng Y, Xia Y, Lee J, Cote G, Wang H, Wang L, Qian C, and Lu Z*. A Splicing Switch from Ketohexokinase-C to Ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology, 5/2016. 18(5):561-71. PMID:2708854. (Highlighted by Cancer Discovery, Science Signaling, and an MD Anderson news release).
4. Liang J, Cao R, Zheng Y, Xia Y, Zheng Y, Li X, Wang L, Yang W* and Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 8/2016, 7:12431. PMID: 27485204
5. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z*. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Molecular Cell. 3/2017, 2;65(5):917-931.PMID: 28238651 (Highlighted by Autophagy and an MD Anderson news release).
6. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, and Lu Z*. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. The Journal of Experimental Medicine. 6/2017. 214 (6), 1843-1855. PMID:28507061.
7. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee J, Li W, Lyu J, Rao G, Zhang X, Qian C, Rozen S, Jiang T, Lu Z*. Nucleus-translocated ACSS2 promotes the gene transcription for lysosomal biogenesis and autophagy. Molecular Cell. 6/2017;66(5):684-697. PMID:28552616. (Highlighted by Nature Reviews Molecular Cell Biology and an MD Anderson news release).
8. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, Groot J, Tao Jiang T, Lu Z*. Stabilization of Phosphofructokinase 1 Platelet Isoform by AKT Promotes Tumorigenesis. Nature Communications. 10/2017; 16;8(1):949. doi: 10.1038/s41467-017-00906-9. PMID: 29038421
9. Wang Y,Guo Y, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee J, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J He J, Xing D*, Tao Y*, Lu Z*. KAT2A Coupled with the a-KGDH Complex Acts as a Histone H3 Succinyltransferase. Nature, 12/2017. 552(7684):273-277. PMID: 29211711 (Highlighted by Cancer Discovery, Faculty of 1000 Prime, and an MD Anderson news release).
10. Qian X, Li X, Tan L, Lee JH, Xia X, Cai Q, Zheng Y, Wang H, Lorenzi P, Lu Z*. Conversion of PRPS hexamer to monomer by AMPK-mediated phosphorylation inhibits nucleotide synthesis in response to energy stress. Cancer Discovery, 1/2018: 8(1):94-107. PMID: 29074724.
11. Lu Z* and Hunter T*. Metabolic Kinases Moonlighting as Protein Kinases. Trends in Biochemical Sciences. 4/2018. (4):301-310. PMID: 29463470.
28. Lee JH, Liu R, Li J., Wang YG, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng y, Chen Q, Lorenzi PL, Mills GB, Jiang T, and Lu Z*. EGFR-phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Molecular Cell, 4/2018 Apr 19;70(2):197-210. PMID: 29677490
12. Li X, Egervari G, Wang Y, Berger SL*, Lu Z*. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nature Reviews Molecular Cell Biology. 9/2018.19(9):563-578. PMID: 29930302
13. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, and Lu Z*. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Molecular Cell, 11/2018. 72 (4): 650-660. PMID: 30392930.
14. Xu D, Li X, Shao F, Lv G, Lv H, Lee J, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H*, Lyu J* and Lu Z*. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Science Advances, 4/2019. 5 (4): eaav4570. PMID: 31032410.
15. Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z*, Hongxia Wang* (* Co-corresponding). TSPAN8 Promotes Cancer Cell Stemness via Activation of Sonic Hedgehog Signaling. Nature Communications, 6/2019. 10(1):2863. PMID: 31253799.
16. Qian X*, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L,Zheng Y, Zhao D, Zhang C, Lorenzi P, You Y, Jiang B, Jiang T, Li H, and Lu Z*. PTEN suppresses glycolysis by dephosphorylating and inhibiting autophosphorylated PGK1. Molecular Cell, 11/2019. 76(3):516-527. PMID: 31492635.
17. Xie Y, Lv X, Ni D, Liu J, Hu Y, Liu Y, Liu Y, Liu R, Zhao H, Lu Z*, Zhou Q*(*Co-corresponding). HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Nature Communications, 9/2019. 10(1):4266. PMID: 31537781.
18. Qian X*, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z*. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. Molecular Cell, 12/2019. 76(6):885-895. PMID:31629659
19. Li X*, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, Depinho R, and Lu Z*. Programmable base editing of mutated TERT promoter inhibits tumor growth. Nature Cell Biology, 2/2020. PMID: 32066906 (Highlighted by Nature Cell Biology, Cancer Research, and Faculty of 1000 Prime).
20. Xu D*, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee J, Du L, Zheng Y, Lv G, Leu J, Wang H, Xing D, Liang T, Hung M*, and Lu Z*. Gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature, 4/2020. 580(7804):530-535. PMID: 32322062.
21. Du L, Lee J, Jiang H, Wang C, Wang S, Zheng Z, Shao F, Xu X, Xia Y, Li J, Zheng Z, Xu Qian X, Li X, Kim H, Xing D, Liu P, Lu Z*, and Lyu J* (* Co-corresponding). b-catenin induces transcriptional expression of PD-L1 to promote tumor immune evasion. Journal of Experimental Medicine, 2020. 217(11):e20191115. PMID: 32860047. (Highlighted in Journal of Experimental Medicine and Rockefeller University News Release).
22. Bian X, Liu R, Meng Y, Xing D, Xu D, and Lu Z. Lipid metabolism and cancer. Journal of Experimental Medicine, 2021. 218 (1): e20201606.
23. Xu D, Shao F, Bian X, Meng Y, Liang T, and Lu Z. The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metabolism, 1/2021. 33(1):33-50. PMID: 33406403.
24.Wang W, Shao F, Yang X, Wang J, Zhu R, Yang Y, Guo D, Sun Y, Wang J2, Xue Q, Gao S, Gao Y, He J, and Lu Z. METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N6-methyladenosine-dependent YTHDF binding. Nature Communications, 6/2021. 12(1):3803. PMID: 34155197.
25.Tong Y, Guo D, Lin SH, Liang J, Yang D, Ma C, Shao F, Li M, Yu Q, Jiang Y, Li L, Fang J, Yu R*, and Lu Z*. SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress of tumor cells. Molecular Cell, 6/2021, 81(11):2303-2316. PMID: 33991485.
26.Liu R*, Lee JH, Yu R, Li J, Tan L, Xia Y, Zheng Y, Bian X, Lorenzi P, Chen Q,* and Lu Z *. Choline kinase alpha 2 acts as a protein kinase to promote the lipolysis of lipid droplets. Molecular Cell, 2021. 7/2021. 81(13):2722-2735. PMID: 34077757 (Highlighted in Molecular Cell).
