个人简介
崔丹蕊，博士，浙江大学附属第一医院浙江省胰腺病研究重点实验室特聘研究员。长期从事CRL泛素连接酶在肿瘤发生发展中的作用、抗肿瘤药物作用机制和肿瘤放化疗增敏机制等方面的研究工作。迄今为止，在国际权威刊物上发表SCI论文14篇，包括Cell Death and Differentiation、Cell Reports、Cell Death & Disease、Oncogene、Molecular Oncology、BBA-Molecular Cell Research和Cell Division等一作或共同一作7篇。作为课题负责人主持国家自然科学基金青年科学基金项目1项。
专业擅长
1.利用基因工程小鼠研究肿瘤的发生发展
2.利用生化分子细胞手段研究肿瘤细胞信号转导
研究方向
1. Cullin-RING Ligase (CRL) E3泛素连接酶在肿瘤发生中的功能
2. Neddylation信号通路在肿瘤发生中的功能
成果奖项：（近五年主要成果及奖励情况）
代表论文（#：共同第一作者；*：通讯作者）
1. Cui D; Dai X; Shu J; Ma Y; Wei D; Xiong X; Zhao Y*; The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth, Cell Death and Differentiation, 2020, 27(3): 1119-1133. (IF=15.828)
2. Cui D#; Xiong X#; Shu J; Dai X; Sun Y; Zhao Y*; FBXW7 confers radiation survival by targeting p53 for degradation, Cell Reports, 2020, 30(2): 497-509. (IF=10.394)
3. Cui D#; Dai X#; Gong L; Chen X; Wang L; Xiong X; Zhao Y*; DEPTOR is a direct p53 target that suppresses cell growth and chemosensitivity, Cell Death & Disease, 2020, 11(11): 976. (IF=8.469)
4. Chen X#; Xiong X#; Cui D#; Yang F; Wei D; Li H; Shu J; Bi Y; Dai X; Gong L; Sun Y; Zhao Y*; DEPTOR is an in vivo tumor suppressor that inhibits prostate tumorigenesis via the inactivation of mTORC1/2 signals, Oncogene, 2020, 39(7): 1557-1571. (IF=9.867)
5. Ma Y#; Cui D#; Xiong X; Inuzuka H; Wei W; Sun Y; North B J*; Zhao Y*; SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation, Molecular Oncology, 2019,13(2): 307-321. (IF= 7.405)
6. Wang J#; Cui D#; Gu S; Chen X; Bi Y; Xiong X; Zhao Y*; Autophagy regulates apoptosis by targeting NOXA for degradation, Biochimica et Biophysica Acta-Molecular Cell Research, 2018, 1865(8): 1105-1113. (IF=6.121)
