个人简介
张蒙博士，浙江大学医学院附属第一院特聘研究员，硕士生导师。博士毕业于中国科学院广州生物医药与健康研究院，曾在以色列魏茨曼科学研究所（Weizmann institute of science, Israel）交流学习。近年来以第一作者在Science Advances、Trends in Cell Biology（共同第一作者）、Stem Cell Research发表文章，以共同作者身份在Cell Stem Cell、Nature Cell Biology、Nature Communications等杂志发表文章。
目前研究方向聚焦于多能干细胞向红细胞分化的方法优化，并探究红系分化过程中的表观和转录调控机制。
专业擅长
擅长干细胞分化、基因编辑等技术。
研究方向
1. 优化多能干细胞向红细胞分化的体系，制备临床级别“人工血液”；
2.利用小分子或CRISPR-Cas9 文库筛选技术探究红系分化过程中的表观和转录调控机制；
3.利用红系分化平台，寻找治疗急性红系白血病的新靶点。
成果奖项：（近五年主要成果及奖励情况）
1. Meng Zhang#, Yiwei Lai#, Vladislav Krupalnik#, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, …. Liang Chen*, Jacob H. Hanna*, Miguel A. Esteban*. β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances, 2020, 6, eaba1593.（IF: 13.116，第一作者）
2. Zhang M, Ibañez DP, Fan W, Liu H, Zhong X, Wang X, Li Y, Md Abdul M, Li W, Li Y, Ward C, Chen S, Wang D, Qin B, Esteban MA, Zhao P, Luo Z*, Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common isoforms abolished. Stem Cell Research, 2019, 41:101602. （IF: 4.489，第一作者）
3. Xu Y#, Zhang M#, Li W, Zhu X, Bao X, Qin B, Hutchins AP, Esteban MA*, Transcriptional Control of Somatic Cell Reprogramming, Trends in Cell Biology, 2016, 26(4): 272-88.（IF: 16.588，共同第一作者）
4. Liu L#, Xu Y#, He M#, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA*, Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming, Cell Stem Cell, 2014, 15: 574-588.
5. He J, Fu X, Zhang M, He F, Li W, Abdul MM, Zhou J, Sun L, Chang C, Li Y, Liu H, Wu K, Babarinde IA, Zhuang Q, Loh YH, Chen J, Esteban MA, Hutchins AP*. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications, 2019, 10(1): 34.
6. Zhuang Q#, Li W#, Benda C#, Huang Z, Ahmed T, Liu P, Guo X, Ibañez DP, Luo Z, Zhang M, Abdul MM, Yang Z, Yang J, Huang Y, Zhang H, Huang D,Zhou J, Zhong X, Zhu X, Fu X, Fan W, Liu Y, Xu Y, Ward C, Khan MJ, Kanwal S, Mirza B, Tortorella MD, Tse HF, Chen J, Qin B, Bao X, Gao S, Hutchins AP*, Esteban MA*, NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming, Nat. Cell Biol, 2018, 20: 400-412.
7. Wu Y#, Li Y#, Zhang H, Huang Y, Zhao P, Tang Y, Qiu X, Ying Y, Li W, Ni S, Zhang M, Liu L, Xu Y, Zhuang Q, Luo Z, Benda C, Song H, Liu B, Lai L, Liu X, Tse HF, Bao X, Chan WY, Esteban MA, Qin B*, Pei D*, Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming, Nat. Cell Biol, 2015，17(6), 715-725.
8. Wang L, Xu X, Jiang C, Ma G, Huang Y, Zhang H, Lai Y, Wang M, Ahmed T, Lin R, Guo W, Luo Z, Li W, Zhang M, Ward C, Qian M, Liu B, Esteban MA, Qin B*, mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. FEBS J, 2020，287(1), 108-121.
9. Luo Z, Qing X, Benda C, Huang Z, Zhang M, Huang Y, Zhang H, Wang L, Lai Y, Ward C, Volpe G, Zhong X, Qin B, Zhuang Q, Esteban MA, Li W*, Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regen (Lond), 2019, 8(1), 21-29.
