个人简介
浙江大学求是讲席教授、博导、国家精准医疗重大专项首席科学家。
李明定教授长期从事以生物信息学和分子数量遗传学为基础的人类遗传学、药理基因组学、神经生物学和遗传流行病学等领域的研究，所领导的复杂疾病遗传和生物信息研究室是世界上第一个用基因芯片和蛋白组学来研究尼古丁对人类以及模式动物基因组影响的研究室，也是第一个用全基因组连锁方法成功地定位美国黑人群体尼古丁成瘾基因的研究室。李明定教授在 Nature Genetics Reviews, Nature Genetics, American Journal of Human Genetics 和 Molecular Psychiatry 等国际重要刊物上以第一作者或通论作者发表SCI学术论文共230多篇，总影响因子约1000，平均每篇5.5，它引高达8000多次，单篇最高600余次，并主编出版了四本英文专著和一本中文专著。
专业擅长
人类复杂疾病的遗传学分析
生物信息学
研究方向
精准医学和个体化医学研究
基因组学和药物基因组学研究
生物信息学
遗传流行病学
人工智能在医学中的应用
成果奖项：（近五年主要成果及奖励情况）
（1） Chen, J., Y. Ma, R. Fan, Z. Yang and M. D. Li (2018). "Implication of Genes for the N-Methyl-D-Aspartate (NMDA) Receptor in Substance Addictions." Mol Neurobiol 55(9): 7567-7578.
（2） Cui, W., Y. Ning, W. Hong, J. Wang, Z. Liu and M. D. Li (2019). "Crosstalk Between Inflammation and Glutamate System in Depression: Signaling Pathway and Molecular Biomarkers for Ketamine's Antidepressant Effect." Mol Neurobiol 56(5): 3484-3500.
（3） Fan, R., W. Cui, J. Chen, Y. Ma, Z. Yang, T. J. Payne, J. Z. Ma and M. D. Li (2020). "Gene-based association analysis reveals involvement of LAMA5 and cell adhesion pathways in nicotine dependence in African- and European-American samples." Addict Biol: e12898.
（4） Fang, Z., Y. Yang, Y. Hu, M. D. Li and J. Wang (2017). "GRONS: a comprehensive genetic resource of nicotine and smoking." Database (Oxford) 2017.
（5） Han, H., Q. Liu, Z. Yang, M. Wang, Y. Ma, L. Cao, W. Cui, W. Yuan, T. J. Payne, L. Li and M. D. Li (2018). "Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers." Transl Psychiatry 8(1): 243.
（6） Han, H., Z. Yang, S. L. Chang and M. D. Li (2018). "Modulatory Effects of Nicotine on neuroHIV/neuroAIDS." J Neuroimmune Pharmacol 13(4): 467-478.
（7） Hu, T., Z. Yang and M. D. Li (2018). "Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control." J Neuroimmune Pharmacol 13(4): 453-466.
（8） Jiang, X., B. Zhang, J. Zhao, Y. Xu, H. Han, K. Su, J. Tao, R. Fan, X. Zhao, L. Li and M. D. Li (2019). "Identification and characterization of SEC24D as a susceptibility gene for hepatitis B virus infection." Sci Rep 9(1): 13425.
（9） Li, J., Y. Ma, Z. Bao, X. Gui, A. N. Li, Z. Yang and M. D. Li (2020). "Clostridiales are predominant microbes that mediate psychiatric disorders." J Psychiatr Res 130: 48-56.
（10） Liu, Q., H. Han, M. Wang, Y. Yao, L. Wen, K. Jiang, Y. Ma, R. Fan, J. Chen, K. Su, Z. Yang, W. Cui, W. Yuan, X. Jiang, J. Li, T. J. Payne, J. Wang and M. D. Li (2018). "Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population." Transl Psychiatry 8(1): 83.
（11） Liu, Q., Y. Xu, Y. Mao, Y. Ma, M. Wang, H. Han, W. Cui, W. Yuan, T. J. Payne, Y. Xu, M. D. Li and Z. Yang (2020). "Genetic and Epigenetic Analysis Revealing Variants in the NCAM1-TTC12-ANKK1-DRD2 Cluster Associated Significantly With Nicotine Dependence in Chinese Han Smokers." Nicotine Tob Res 22(8): 1301-1309.
（12） Liu, W. and M. D. Li (2018). "Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment." Curr Neuropharmacol 16(4): 350-370.
（13） Ma, Y., J. Li, Y. Xu, Y. Wang, Y. Yao, Q. Liu, M. Wang, X. Zhao, R. Fan, J. Chen, B. Zhang, Z. Cai, H. Han, Z. Yang, W. Yuan, Y. Zhong, X. Chen, J. Z. Ma, T. J. Payne, Y. Xu, Y. Ning, W. Cui and M. D. Li (2020). "Identification of 34 genes conferring genetic and pharmacological risk for the comorbidity of schizophrenia and smoking behaviors." Aging (Albany NY) 12(3): 2169-2225.
（14） Ma, Y. and M. D. Li (2017). "Establishment of a Strong Link Between Smoking and Cancer Pathogenesis through DNA Methylation Analysis." Sci Rep 7(1): 1811.
（15） Pan, Z., M. Zhao, Y. Peng and J. Wang (2019). "Functional divergence analysis of vertebrate neuronal nicotinic acetylcholine receptor subunits." J Biomol Struct Dyn 37(11): 2938-2948.
（16） Wang, M., J. Zhao, Y. Wang, Y. Mao, X. Zhao, P. Huang, Q. Liu, Y. Ma, Y. Yao, Z. Yang, W. Yuan, W. Cui, T. J. Payne and M. D. Li (2020). "Genome-wide DNA methylation analysis reveals significant impact of long-term ambient air pollution exposure on biological functions related to mitochondria and immune response." Environ Pollut 264: 114707.
（17） Wen, L., H. Han, Q. Liu, K. Su, Z. Yang, W. Cui, W. Yuan, Y. Ma, R. Fan, J. Chen, K. Jiang, X. Jiang, T. J. Payne, J. Wang and M. D. Li (2017). "Significant association of the CHRNB3-CHRNA6 gene cluster with nicotine dependence in the Chinese Han population." Sci Rep 7(1): 9745.
（18） Xu, Y., L. Cao, X. Zhao, Y. Yao, Q. Liu, B. Zhang, Y. Wang, Y. Mao, Y. Ma, J. Z. Ma, T. J. Payne, M. D. Li and L. Li (2020). "Prediction of Smoking Behavior From Single Nucleotide Polymorphisms With Machine Learning Approaches." Front Psychiatry 11: 416.
（19） Yang, Z., J. Li, X. Gui, X. Shi, Z. Bao, H. Han and M. D. Li (2020). "Updated review of research on the gut microbiota and their relation to depression in animals and human beings." Mol Psychiatry 25(11): 2759-2772.
（20） Yang, Z., T. Nesil, T. Wingo, S. L. Chang and M. D. Li (2017). "HIV-1 Proteins Influence Novelty-Seeking Behavior and Alter Region-Specific Transcriptional Responses to Chronic Nicotine Treatment in HIV-1Tg Rats." Nicotine Tob Res 19(9): 1024-1032.
（21） Yao, Y., Y. Xu, Z. Cai, Q. Liu, Y. Ma, A. N. Li, T. J. Payne and M. D. Li (2020). "Determination of shared genetic etiology and possible causal relations between tobacco smoking and depression." Psychol Med: 1-10.
（22） Yao, Y., Y. Xu, J. Zhao, Y. Ma, K. Su, W. Yuan, J. Z. Ma, T. J. Payne and M. D. Li (2018). "Detection of Significant Association Between Variants in Cannabinoid Receptor 1 Gene (CNR1) and Personality in African-American Population." Front Genet 9: 199.
Zhao, X., M. Xu, Z. Cai, W. Yuan, W. Cui and M. D. Li (2019). "Identification of LIFR, PIK3R1, and MMP12 as Novel Prognostic Signatures in Gallbladder Cancer Using Network-Based Module Analysis." Front Oncol 9: 325.
