个人简介

  浙江大学医学院附属第一医院生物医学大数据中心负责人。2009年，赴法国巴黎国家测序中心和人类多态性研究中心(CEPH)从事高通量数据分析研究工作。2011年-2014年，于哈佛大学公共卫生学院从事博士后研究工作。2014年回国，受聘于上海交通大学医学院附属瑞金医院血研所。担任中国医药生物技术协会基因检测技术分会委员、中国病理生理学会实验血液学青年委员会委员和中-法应用科学会(FFCSA)俱乐部主席。研发了一系列医疗卫生软件系统，在《Cancer Cell》、《Genome Biology》、《PNAS》和《Bioinformatics》等学术刊物以第一或通讯作者发表SCI论文50余篇，总影响因子超过500，共同主编了《R语言在生物医学领域的应用》一书。取得软件著作权2项，申请专利6项。

专业擅长

擅长高通量数据分析研究，以及生物医学大数据整合与挖掘。

研究方向

  组学数据的分析与挖掘，恶性肿瘤分子分型和发病机制研究。

成果奖项：（近五年主要成果及奖励情况）

一、成果

（一）发表文章

2021年

1. Sangyoon Yi, Xianyang Zhang, Lu Yang, Jinyan Huang, Yuanhang Liu, Chen Wang, Daniel J. Schaid, Jun Chen, 2dFDR: a new approach to confounder adjustment substantially increases detection power in omics association studies, Genome Biology, July 13. doi: https://doi.org/10.1186/s13059-021-02418-8. (期刊影响因子：14.2)

2. Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang, Clinical significance of CD34 + CD117 dim/CD34 + CD117 bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia, Frontiers of Medicine, Mar 23. doi: 10.1007/s11684-021-0836-7. (期刊影响因子：3.42)

3. Hao Tang, Yijun Cheng, Jinyan Huang, Jianfeng Li, Benyan Zhang, Zhe Bao Wu, Case Report: Temozolomide Treatment of Refractory Prolactinoma Resistant to Dopamine Agonists, Front Endocrinol. 2021 Mar 12;12:616339. doi: 10.3389/fendo.2021.616339. (期刊影响因子：3.675)

4. Liang Wu, Minghao Jiang, Ping Yu, Jianfeng Li, Wen Ouyang, Chong Feng, Wei Li Zhao, Yuting Dai and Jinyan Huang*, Single-Cell Transcriptome Analysis Identifies Ligand–Receptor Pairs Associated With BCP-ALL Prognosis, Frontiers in Oncology, 2021 Mar 10;11:639013. doi: 10.3389/fonc.2021.639013. eCollection 2021 (通讯作者，期刊影响因子：4.848)

5. Yuting Dai, Aining Xu, Jianfeng Li, Liang Wu, Shanhe Yu, Jun Chen, Weili Zhao, Xiao-Jian Sun and Jinyan Huang*, CytoTree: an R/Bioconductor package for analysis and visualization of flow and mass cytometry data, BMC Bioinformatics, 2021 Mar 22;22(1):138. doi: 10.1186/s12859-021-04054-2. (通讯作者，期刊影响因子：3.242)

6. Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Jinyan Huang* and Sai-Juan Chen*, Emerging Molecular Subtypes and Therapeutic Targets in B-cell Precursor Acute Lymphoblastic Leukemia, Frontiers of Medicine, 2021 Jan 5. doi: 10.1007/s11684-020-0821-6. (共同通讯作者，期刊影响因子：3.42)

2020年

7. Yaohui huang, Kun Cai, PengPeng Xu, Li Wang, ChuanXin Huang, Ying Fang, Shu Cheng, Xiao-Jian Sun, Feng Liu, Jinyan Huang, and MengMeng Ji, Wei-Li Zhao, CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis, Signal Transduction and Targeted Therapy, 2020 Nov;10(7):e221.doi: 10.1002/ctm2.221. (期刊影响因子：13.49)

8. Rong Shen, Peng-Peng Xu, Nan Wang, Hong-Mei Yi, Lei Dong, Di Fu, Jinyan Huang, Heng-Ye Huang, Anne Janin, Shu Cheng, Li Wang, Wei-Li Zhao, Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B-cell lymphoma, Clinical and Translational Medicine, 2020 Nov;10(7):e221.doi: 10.1002/ctm2.221. (期刊影响因子：7.92)

9. Lu Jiang, Xue-Ping Li, Yu-Ting Dai, Jinyan Huang*, Zhu Chen* and Sai-Juan Chen*, Multidimensional Study of the Heterogeneity of Leukemia Cells in t(8;21) AML Identifies the Subtype with Poor Outcome, PNAS, 2020 Aug 18;117(33):20117-20126. doi: 10.1073/pnas.2003900117. (共同通讯作者，期刊影响因子：9.58)

10. Mingjie Wang, Jianfeng Li, Xiaonan Zhang, Yue Han, Demin Yu, Donghua Zhang, Zhenghong Yuan, Zhitao Yang, Jinyan Huang* and Xinxin Zhang*, An integrated software for virus community sequencing data analysis, BMC Genomics, 2020 May 15;21(1):363. doi: 10.1186/s12864-020-6744-4. (共同通讯作者，期刊影响因子：3.68)

11. Li SX, Chen XJ, Jiang L, Lei YC, Zhang YX, Dai B, Zhang WN, Zhong ML, Fan YL, Chen QS, Liu H, Jinyan Huang, Chen B, Identification of a t(X;17)(q28;q21) generating a KANSL1-MTCP1 gene fusion leading to dysregulated expression of MTCP1 in acute myeloid leukemia, Genes Chromosomes Cancer, 2020 Jul;59(7):417-421. doi: 10.1002/gcc.22840. (期刊影响因子：3.56)

12. Chang R, Wang H, Zhang S, Wang Z, Dong Y, Tsamlag L, Yu X, Xu C, Yu Y, Long R, Liu NN, Chu Q, Wang Y, Xu G, Shen T, Wang S, Deng X, Jinyan Huang, Zhang X, Wang H, Cai Y. Phase- and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China. Frontiers of Medicine, 2020 Apr;14(2):199-209. doi: 10.1007/s11684-020-0768-7. (期刊影响因子：3.54)

13. Kai Duan, Bende Liu, Cesheng Li, Huajun Zhang, Ting Yu, Jieming Qu, Min Zhou, Li Chen, Shengli Meng, Yong Hu, Cheng Peng, Mingchao Yuan, Jinyan Huang, Zejun Wang, Jianhong Yu, Xiaoxiao Gao, Dan Wang, Xiaoqi Yu, Li Li, Jiayou Zhang, Xiao Wu, Bei Li, Yanping Xu, Wei Chen, Yan Peng, Yeqin Hu, Lianzhen Lin, Xuefei Liu, Shihe Huang, Zhijun Zhou, Lianghao Zhang, Yue Wang, Zhi Zhang, Kun Deng, Zhiwu Xia, Qin Gong, Wei Zhang, Xiaobei Zheng, Ying Liu, Huichuan Yang, Dongbo Zhou, Ding Yu, Jifeng Hou, Zhengli Shi, Saijuan Chen, Zhu Chen*, Xinxin Zhang*, and Xiaoming Yang*, Effectiveness of convalescent plasma therapy in severe COVID-19 patients, PNAS. 2020 Apr 28;117(17):9490-9496. doi: 10.1073/pnas.2004168117. (期刊影响因子：9.58)

14. Jinyan Huang*, Ling Bai, Bowen Cui, Liang Wu, Liwen Wang, Zhiyin An, Shulin Ruan, Yue Yu, Xianyang Zhang, Jun Chen, Leveraging biological and statistical covariates improves the detection power in epigenome-wide association testing, Genome Biology, 2020 Apr 6;21(1):88. doi: 10.1186/s13059-020-02001-7. (第一作者、通讯作者，期刊影响因子：14.03)

15. Jie Xiong#, Bo-Wen Cui#, Nan Wang#, Yu-Ting Dai#, Hao Zhang#, Chao-Fu Wang#, Hui-Juan Zhong, Shu Cheng, Bin-Shen Ou-Yang, Yu Hu, Xi Zhang, Bin Xu, Wen-Bin Qian, Rong Tao, Feng Yan, Jian-Da Hu, Ming Hou, Xue-Jun Ma, Xin Wang, Yuan-Hua Liu, Zun-Min Zhu, Xiao-Bin Huang, Li Liu, Chong-Yang Wu, Li Huang, Yun-Feng Shen, Rui-Bin Huang, Jing-Yan Xu, Chun Wang, De-Pei Wu, Li Yu, Jian-Feng Li, Peng-Peng Xu, Li Wang, Jinyan Huang*, Sai-Juan Chen*, and Wei-Li Zhao*, Genomic and Transcriptomic Characterization of Natural Killer T Cell Lymphoma, Cancer Cell, 2020 Mar 16;37(3):403-419.e6. doi: 10.1016/j.ccell.2020.02.005. (共同通讯作者，期刊影响因子：26.6)

16. Huwen Wang, Zezhou Wang, Yinqiao Dong, Ruijie Chang, Chen Xu, Xiaoyue Yu, Shuxian Zhang, Lhakpa Tsamlag, Meili Shang, Jinyan Huang, Ying Wang, Gang Xu, Tian Shen, Xinxin Zhang, Yong Cai, Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China, Cell Discovery, 2020 Feb 24;6:10. doi: 10.1038/s41421-020-0148-0. (期刊影响因子：4.6)

2019年

17. Yi Zhou, Xingli Zhu, Yuting Dai, Shumin Xiong, Chuijin Wei, Pei Yu, Yuewen Tang, Liang Wu, Jianfeng Li, Dan Liu, Yanlin Wang, Zhu Chen, Sai-Juan Chen*, Jinyan Huang*, and Lin Cheng*, Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells. Advanced Science. 2019 Nov 11;7(1):1901785. doi: 10.1002/advs.201901785. eCollection 2020 Jan. (共同通讯作者，期刊影响因子：15.8)

18. Chen-Lei Wen, et.al., Jinyan HUANG, et.al., Sai-Juan Chen, Zhu Chen*, Min Lik*, Yuan Fang*, Bai-Yong Shen*, and Lu Zhou*, An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma. PNAS. 2019 Nov 12;116(46):23264-23273. doi: 10.1073/pnas.1914557116. Epub 2019 Oct 29. (期刊影响因子：9.58)

19. Yao H, Tang H, Zhang Y, Zhang QF, Liu XY, Liu YT, Gu WT, Zheng YZ, Shang HB, Wang Y, Jinyan HUANG, Wei YX, Zhang X, Zhang J, Wu ZB, DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma, Cancer Lett. 2019 Sep 10;459:135-144. doi: 10.1016/j.canlet.2019.05.043. Epub 2019 Jun 6. (期刊影响因子：6.5)

20. Merino J, Dashti HS, et.al., Jinyan Huang, et.al., Chu AY, Tanaka T, Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Molecular Psychiatry. 2019 Dec;24(12):1920-1932. doi: 10.1038/s41380-018-0079-4. Epub 2018 Jul 9. (期刊影响因子：12)

21. Clark DW, Okada Y, Moore KHS, et.al., Jinyan Huang, et.al., Joshi PK, Kubo M, Wilson JF, Associations of autozygosity with a broad range of human phenotypes, Nature Communication. 2019 Oct 31;10(1):4957. doi: 10.1038/s41467-019-12283-6. (期刊影响因子：11.9)

22. Wang D, Zhang G, Gu J, Shao X, Dai Y, Li J, Pan X, Yao S, Xu A, Jin Y, Jinyan Huang, Shi Q, Zhu J, Xi X, Chen Z, Chen S., In vivo generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A. Haematologica. 2019 Jul 11. pii: haematol.2019.219089. doi: 10.3324/haematol.2019.219089. (期刊影响因子：7.57)

2018年

23. Jianfeng Li#,Yu-Ting Daia, Henrik Lilljebjörnb, Shu-Hong Shen, Bo-Wen Cui, Ling Bai, Yuan-Fang Liu, Mao-Xiang Qian, Yasuo Kubota, Hitoshi Kiyoi, Itaru Matsumura, Yasushi Miyazaki, Linda Olsson, Ah Moy Tan, Hany Ariffin, Jing Chen, Junko Takita, Takahiko Yasuda, Hiroyuki Mano, Bertil Johansson, Jun J. Yang, Allen Eng-Juh Yeoh, Fumihiko Hayakawa, Zhu Chen*, Ching-Hon Pui*, Thoas Fioretos*, Sai-Juan Chen*, Jinyan Huang*, Transcriptional landscape of B-cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases. PNAS. 2018 Dec 11;115(50):E11711-E11720. doi: 10.1073/pnas.1814397115. Epub 2018 Nov 28. (通讯作者，期刊影响因子：9.58)

24. Jianfeng Li#,et.,al, Jinyan Huang*, BioInstaller: a comprehensive R package to construct interactive and reproducible biological data analysis applications based on the R platform. Peerj. 2018 Oct 31; 6:e5853. (通讯作者，期刊影响因子：2.353)

25. Huizhuang Shan, et.,al, Jinyan Huang, et.,al, Yingli Wu, USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia. Signal Transduction and Targeted Therapy. 2018 Oct 26;3:29. doi: 10.1038/s41392-018-0028-3. eCollection 2018. (期刊影响因子：5.873)

26. Dong X#, Zhang W#, Wu H#, Jinyan Huang#, Zhang M, Wang P, Zhang H, Chen Z, Chen SJ, Meng G, Structural basis of DUX4/IGH-driven transactivation. Leukemia. 2018 Jun;32(6):1466-1476. (共同第一，期刊影响因子：9.944)

27. Meng-Meng Ji#, Yao-Hui Huang#, Jinyan Huang#, Zhao-Fu Wang, Di Fu, Han Liu, Feng Liu, Christophe Leboeuf, Li Wang, Jing Ye, Yi-Ming Lu, Anne Janin, Shu Cheng and Wei-Li Zhao, Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified. Haematologica. 2018 Apr;103(4):679-687. (共同第一，期刊影响因子：7.570)

28. Merino J, Dashti HS, et.al., Jinyan HUANG, et.al., Chu AY, Tanaka T., Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium. Mol Psychiatry. 2019 Dec;24(12):1920-1932. (期刊影响因子：11.973)

29. Wang S, Zhang YX, Huang T, Sui JN, Lu J, Chen XJ, Wang KK, Xi XD, Li JM, Jinyan Huang*, Chen Bin*, Mutation profile and associated clinical features in Chinese patients with cytogenetically normal acute myeloid leukemia. Int J Lab Hematol. 2018 Aug;40(4):408-418. (共同通讯作者，期刊影响因子：2.073)

2017年

30. Bing Chen, Lu Jiang, Meng-Ling Zhong, Jian-Feng Li, Ben-Shang Li, Li-Jun Peng, Yu-Ting Dai, Bo-Wen Cui, Tian-Qi Yan, Wei-Na Zhang, Xiang-Qin Weng, Yin-Yin Xie, Jing Lu, Rui-Bao Ren, Su-Ning Chen, Jian-Da Hu, De-Pei Wu, Zhu Chen*, Jing-Yan Tang*, Jinyan Huang*, Jian-Qing Mi*, Sai-Juan Chen*, Identification of fusion genes and characterization of transcriptome features in T-cell acute lymphoblastic leukemia. PNAS. 2018 Jan 9;115(2):373-378. (共同通讯作者，期刊影响因子：9.58)

31. Jun Chen, Ehsan Behnam, Jinyan Huang, Miriam F. Moffatt, Daniel J. Schaid, Liming Liang and Xihong Lin, Fast and robust adjustment of cell mixtures in epigenome-wide association studies with SmartSVA. BMC Genomics. 2017 May 26;18(1):413. (期刊影响因子：3.501)

32. Yu-Jun Dai#, Yue-Ying Wang#, Jinyan Huang#, Li Xia, Xiao-Dong Shi, Jie Xu, Jing Lu, Xian-Bin Su, Ying Yang, Wei-Na Zhang, Pan-Pan Wang, Song-Fang Wu, Ting Huang, Jian-Qing Mi, Ze-Guang Han, Zhu Chen, and Sai-Juan Chen, Conditional knock-in of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. PNAS. 2017 May 16;114(20):5237-5242. (共同第一，期刊影响因子：9.58)

33. Yong‑Mei Zhu, Pan‑Pan Wang, Jinyan Huang, et.al., Sai-Juan Chen and Yang Shen, Gene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance. Journal of Translational Medicine. 2017 Aug 22;15(1):178. (期刊影响因子：4.098)

34. Mingjie WANG, et al., Jinyan Huang*, Xinxin ZHANG*, Characterization of gene expression profiles in HBV-related liver fibrosis patients and identification of ITGBL1 as a key regulator of fibrogenesis. Scientific Reports. 2017 Mar 6;7:43446. (共同通讯作者，期刊影响因子：4.011)

35. Omer Schwartzman, Angela Maria Savino, Michael Gombert, Chiara Palmi, Gunnar Cario, Martin Schrappe, Cornelia Eckert, Arend von Stackelberg, Jinyan Huang, Michal Hameiri-Grossman, Smadar Avigad, Geertruy te Kronnie, Ifat Geron, Yehudit Birger, Avigail Rein, Giulia Zarfati, Ute Fischer, Zohar Mukamel, Martin Stanulla, Andrea Biondi, Giovanni Cazzaniga, Amedeo Vetere, Bridget K. Wagner, Zhu Chen, Sai-Juan Chen, Amos Tanay, Arndt Borkhardt, and Shai Izraeli, Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. PNAS. 2017 May 16;114(20):E4030-E4039. (期刊影响因子：9.58)

36. Peng-Peng Xu, Hui-Juan Zhong, Yao-Hui Huang, Xiao-Dong Gao, Xia Zhao, Yang Shen, Shu Cheng, Jinyan Huang, Sai-Juan Chen, Li Wang, Wei-Li Zhao, B-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma: A Retrospective Cohort Study. Ebiomedicine. 2017 Feb;16:106-114. (期刊影响因子：6.680)

37. Peng-Peng Xu, Hui-Juan Zhong, Yao-Hui Huang, Xiao-Dong Gao, Xia Zhao, Yang Shen, Shu Cheng, Jinyan Huang, Sai-Juan Chen, Li Wang, Wei-Li Zhao, A low-frequency inactivating AKT2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk. Diabetes. 2017 Jul;66(7):2019-2032. (期刊影响因子：7.199)

38. Jun Li, Xiaoyan Zhu, Kuai Yu, Haijing Jiang, Yizhi Zhang, Siyun Deng, Longxian Cheng, Xuezhen Liu, Jia Zhong, Xiaomin Zhang, Mei'an He, Weihong Chen, Jing Yuan, Ming Gao, Yansen Bai, Xu Han, Bing Liu, Xiaoting Luo, Wenhua Mei, Xiaosheng He, Shunchang Sun, Liyun Zhang, Hesong Zeng, Huizhen Sun, Chuanyao Liu, Yanjun Guo, Bing Zhang, Zhihong Zhang, Jinyan Huang, An Pan, Yu Yuan, Francesca Angileri, Bingxia Ming, Fang Zheng, Qiutang Zeng, Xiaobo Mao, Yudong Peng, Yi Mao, Ping Ye, Qing K Wang, Lu Qi, Frank B Hu, Liming Liang, Tangchun Wu, Genome-Wide Analysis of DNA Methylation and Acute Coronary Syndrome. Circulation Research. 2017 May 26;120(11):1754-1767. (期刊影响因子：15.862)

39. Lindström S, Loomis S, Turman C, Huang H, Jinyan Huang, Aschard H, Chan AT5, Choi H, Cornelis M, Curhan G, De Vivo I, Eliassen AH, Fuchs C, Gaziano M11, Hankinson SE, Hu F, Jensen M, Kang JH8, Kabrhel C, Liang L, Pasquale LR, Rimm E, Stampfer MJ, Tamimi RM, Tworoger SS, Wiggs JL, Hunter DJ, Kraft P, A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PloS One. 2017 Mar 16;12(3):e0173997. (期刊影响因子：2.776)

2016年

40. Li Man, et al., Jinyan Huang, et al., SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol. 2017 Mar;28(3):981-994. (期刊影响因子：8.547)

41. Pan M, et al., Jinyan Huang, et al., Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway, Leukemia. 2016 Jul;30(7):1590-3. (期刊影响因子：9.944)

42. Pan M, et al., Jinyan Huang, et al., Inhibition of the nuclear export of p65 and IQCG in leukemogenesis by NUP98-IQCG. Front Med. 2016 Dec;10(4):410-419. (期刊影响因子：1.847)

43. Wu M, et al., Jinyan Huang, et al., N-Arachidonoyl Dopamine Inhibits NRAS Neoplastic Transformation by Suppressing Its Plasma Membrane Translocation. Mol Cancer Ther. 2017 Jan;16(1):57-67. (期刊影响因子：4.856)

44. Fuchsberger C, et al., Jinyan Huang, et al., The genetic architecture of type 2 diabetes. Nature. 2016 Aug 4;536(7614):41-47. (期刊影响因子：43.070)

45. Yuanfang Liu, et al., Jinyan Huang, et al., Genomic Profiling of Adult and Pediatric B-cell Acute Lymphoblastic Leukemia. Ebiomedicine. 2016 Jun;8:173-183. (共同通讯作者，期刊影响因子：6.680)

46. Machiela MJ, et al., Jinyan Huang, et al., Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes. Human Molecular Genetics. 2016 Apr 15;25(8):1663-76. (期刊影响因子：4.544)

47. Berndt SI, et al., Jinyan Huang, et al., Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. Nature Communication. 2016 Mar 9;7:10933. (期刊影响因子：11.878)

48. Felix JF, et al., Jinyan Huang, et al., Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics. 2016 Jan 15;25(2):389-403. (期刊影响因子：4.544)

（二）科研项目

1. 题目: 基于分子分型的脑胶质瘤和急性白血病精准诊断，SQ2019YFE010340

2020/01-2022/12，科技部国家重点研发计划项目，800万元

参与情况: 子课题负责人

2. 题目: 急性T淋巴细胞白血病的基因组及转录组生物信息学分析方法建立及数据分析，82070147

2021/01-2024/12，国家自然科学基金面上项目，55万元

参与情况: 项目负责人

3. 题目: 急性B淋巴细胞白血病(BCP-ALL)的分子分型研究，20161303R

2019/01-2021/12，上海市科委“临床专职科研队伍”双百人项目，130万元

参与情况: 项目负责人

4. 题目: 急性T淋巴细胞白血病(T-ALL)的分子分型研究，20161303

2016/01-2018/12，上海市科委“临床专职科研队伍”双百人项目，130万元

参与情况: 项目负责人

5. 题目: 基于全基因组测序建立病毒拷贝数和整合位点的生物信息学方法及数据分析，81770205

2018/01-2021/12，国家自然科学基金面上项目，55万元

参与情况: 项目负责人

6. 题目: 成人及儿童急性淋巴细胞白血病的基因组转录组生物信息学分析方法建立及数据分析, 81570122

2016/01-2019/12，国家自然科学基金面上项目，60万元

参与情况: 项目负责人

12月，国家重点研发计划，320万元

参与情况: 项目骨干

7. 题目: 诱导多能干细胞基因和信号调控网络的研究, 30900838

2010/01-2012/12，国家自然科学基金青年项目，20万元

参与情况: 项目负责人

（三）研发专利及软件著作权

1. 用于下载、安装、管理生物信息软件、数据库的方法及系统（2018年）

2. 一种生物信息数据库注释方法及系统（2018年）

3. 基于RNA-seq数据的肿瘤基因突变检测方法及系统（2018年）

4. 阿尔法医生基因检测系统（2016年）

5. 阿尔法医生基因检测报告系统（2016年）

二、奖励

2018 首届“转化医学奖励计划”创新奖

2018 国家科学技术进步二等奖(排名第四)。

2018 长木(Long wood, Boston)学术奖

2018 湘医联盟杰出人才奖

2016 上海市教育委员会高峰高原学科人才建设计划，编号：20161303

2015 上海浦江人才，编号：15PJ1405300

2015 上海高校青年东方学者，编号：QD2015005

2014 Gilles kahn Prize吉尔·卡恩科学奖, Sino French Foundation for Science and its Applications (FFCSA).

社会任职

1. Frontiers in Genetics杂志Guest Associate Editor（2021年）

2. 中国抗癌协会病理专业委员会肿瘤分子病理协作组委员（2019年）

3. 上海交通大学-耶鲁大学生物统计和数据科学联合中心研究员（2019年）

4. 中国医药生物技术协会基因检测技术分会委员（2018年）

5. 法中应用科学会(FFCSA)俱乐部主席（2018年）

6. 中国病理生理学会实验血液学青年委员会委员（2017年）