个人简介
率先在国内开展以One Health理念为指导的耐药机制和感染微生态学研究，近年来承担国家重点研发计划课题、国家自然科学基金（3项）、基础加强项目子课题等7项国家级课题（经费＞1000万），以及浙江省自然、Wellcome Trust等9项非国家级课题，迄今在Engineering, Protein & Cell, Lancet Infec Dis, mSystems, Clin Infec Dis, Environ Pollu, J Antimicrob Chemother等领域著名SCI刊物发表论文110余篇（一作/共一/通讯/共通讯60篇），引用~2400，累计影响因子>500, h-index: 24。在细菌耐药机制、微生物基因组研究方面取得创新性成绩，任多个国家级学会分会青委，多个SCI/核心期刊编委/青委，获浙江省科技奖二等奖2项（第二完成人）, 浙江省医药卫生科技奖一等奖 1项（第二完成人）。
专业擅长
细菌耐药与感染微生态学研究
研究方向
1. “One Health”策略下的耐药播散研究：揭示病原微生物跨领域传播问题；
2. 感染微生态学研究：阐明人体微生物组及耐药组在疾病发生发展中的作用机制；
病原体毒力机制研究：阐明多类临床重要病原微生物毒力机制及生物学特征。
成果奖项：（近五年主要成果及奖励情况）
近5年论文发表情况 (累计发表相关通讯（含共通讯）及一作（含共一）论文43篇，#第一作者；*通讯作者)
1) 江夏薇，刘文洪，徐浩，崔新洁，陈炬蓉，郑焙文*Characterizations of heavy metal contamination, microbial community, and resistance genes in a tailing of the largest copper mine in China. Environ Pollut, 2021.
2) 郑焙文#，刘文洪，徐浩，李俊峰，江夏薇*，Occurrence and distribution of antimicrobial resistance genes in the soil of an industrial park in China: A metagenomics survey. Environ Pollut, 2021. 273: p. 116467.
3) Li P#, Liang Q#, Liu W#, Zheng B#, Liu L, Wang W, Xu Z, Huang M, Feng Y*, Convergence of carbapenem resistance and hypervirulence in a highly-transmissible ST11 clone of K. pneumoniae: An epidemiological, genomic and functional study. Virulence 2021, 12(1):377-388.
4) 郑焙文#，徐浩#，郭丽华，尉骁，嵇金如，应超群，陈云波，沈萍，韩慧明，黄晨，张舜天，吕涛，肖永红*，Genomic and Phenotypic Diversity of Carbapenemase-Producing Enterobacteriaceae Isolates from Bacteremia in China: A Multicenter Epidemiological, Microbiological and Genetic Study, Engineering, 202010.
5) 郑焙文#，徐浩#，吕涛#，郭丽华，尉骁，黄晨，张舜天，陈云波，韩慧明，沈萍，肖永红*，李兰娟，Stool Samples of Acute Diarrhea Inpatients as a Reservoir of ST11 Hypervirulent KPC-2-producing Klebsiella pneumoniae, mSystems.
6) 金晔，尉骁，张舜天，陈薇薇，孔晓阳，罗琦霞，郑焙文*，肖永红*，Comparative Analysis of Virulence and Toxin Expression of Vancomycin-Intermediate and Vancomycin-Sensitive Staphylococcus aureus Strains, Frontiers in Microbiology, volume 11, 30 October 2020.
7) 迟小惠#，张静#，徐浩，尉骁，沈萍，嵇金如，应超群，郑焙文*，肖永红，Emergence of KPC-2-Producing Raoultella ornithinolytica Isolated from a Hospital Wastewater Treatment Plant, Antimicrobial Agents And Chemotherapy, 202002, 64(2), e01983-19.
8) 吴晓梁，韩慧明，陈春雷，郑焙文*，Genomic characterisation of a colistin-resistant Klebsiella pneumoniae ST11 strain co-producing KPC-2, FloR, CTX-M-55, SHV-12, FosA and RmtB causing a lethal infection, Journal of Global Antimicrobial Resistance, 201912, 19, 78-80.
9) 冯春燕#，文佩佩#，尉骁，徐浩，李爽，林祥梅，吴绍强*，郑焙文*，Emergence and comparative genomics analysis of ESBL-producing Escherichia coli carrying mcr-1 in Fennec fox imported from Sudan to China，mSphere, 4, 201911.
10) 郑焙文#，徐浩#，黄晨#，尉骁，郭丽华，韩慧明，张静，江夏薇，陈春雷，肖永红*，Occurrence and genomics characterization of two MCR-1-producing Escherichia coli isolates from the same mink farmer，mSphere, 4, 201911.
11) 王爽#，徐留臣#，迟小惠，李岩，寇增强，候配斌，解恒杰*，毕振旺*，郑焙文*，Emergence of NDM-1- and CTX-M-3-Producing Raoultella ornithinolytica in Human Gut Microbiota, Frontiers in Microbiology, 201911.
12) 江夏薇，崔新洁，刘文洪，徐浩，郑焙文*, Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment, Infection and Drug Resistance, 201910, 12: 2775-2779.
13) 胡新俊#，尉骁#，商一冰，徐浩，郭丽华，梁一乐，康艺馨，宋丽，孙继峰，岳峰，毛毅敏*，郑焙文*, Emergence and Characterization of a Novel IncP-6 Plasmid Harboring blaKPC-2 and qnrS2 Genes in Aeromonas taiwanensis Isolates, Frontiers in Microbiology, 2019，10: 2132.
14) 尉骁#，郑焙文#，张静，徐浩，周燕子，肖婷婷，张舜天，朱云颖，王媛，肖永红*，Comprehensive Genome Analysis of Carbapenem-Resistant Raoultella spp. strains, an Emerging Multidrug-Resistant Bacteria in Hospitals, Antimicrobial Agents and Chemotherapy, 201909. pii: AAC.01367-19.
15) 袁世超，吴贵阳，郑焙文*, Complete genome sequence of an IMP-8, CTX-M-14, CTX-M-3 and QnrS1 co-producing Enterobacter asburiae isolate from a patient with wound infection, Journal of Global Antimicrobial Resistance, 201909, 1852-54.
16) 邹慧云#，郑焙文#，孙明丽，Ottoson J，李玉波，Berglund B，迟小惠，姬祥，李学文*，Stalsby Lundborg C，Nilsson L.E, Evaluating Dissemination Mechanisms of Antibiotic-Resistant Bacteria in Rural Environments in China by Using CTX-M-Producing Escherichia coli as an Indicator, Microb Drug Resist, 201909, 25(7), 975-984.
17) 郑焙文，陈云波，Violetta L，肖永红*，李兰娟, Bloodstream infections caused by Entero-bacteriaceae in China, The Lancet Infectious Diseases, 201908, 19(8), 810-811.
18) 姬祥#，郑焙文#，Berglund B，邹慧云，孙强，迟小惠，Ottoson J，李学文*，Lundborg C.S ，Nillsson L.E, Dissemination of extended-spectrum Β-lactamase-producing Escherichia coli carrying mcr-1 among multiple environmental sources in rural China and associated risk to human health, Environmental Pollution, 201908, 251619-627.
1) 江夏薇，崔新洁，徐浩，刘文红，陶芳芳，邵铁娟，潘小平，郑焙文*, Whole Genome Sequencing of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Isolated From a Wastewater Treatment Plant in China, Frontiers in Microbiology, 2019, 10: 1797.
19) 毕晟，姚鑫，黄晨，郑霞，宣天明，盛吉芳，徐凯进，郑焙文*，杨青*, Antagonistic effect between tigecycline and meropenem: successful management of KPC-producing Klebsiella pneumoniae infection, Infection, 201906, 47(30), 497-500.
20) 郭小兵#，饶玉婷#，郭丽华，徐浩，吕涛，尉骁，陈云波，刘娜，韩慧明，郑焙文*, Detection and genomic characterization of a Morganella Morganii isolate from China that produces NDM-5, Frontiers in Microbiology, 2019, 10: 1156.
21) 郑焙文，冯友军, MCR-1-producing Salmonella Typhimurium ST34 links animal foods to human community infections, EBioMedicine, 201904, 4210-11.
22) 郑焙文#，冯春燕#，徐浩#，尉骁，郭丽华，江夏薇，宋晓晖*, Detection and characterization of ESBL-producing Escherichia coli expressing mcr-1 from dairy cows in China, Journal of Antimicrobial Chemotherapy, 201902, 74(2), 321-325.
23) 江夏薇，程虹，霍莹莹，徐玲，吴岳红，刘文红，陶芳芳，崔新洁，郑焙文*, Biochemical and genetic characterization of a novel metallo-β-lactamase from marine bacterium Erythrobacter litoralis HTCC 2594, Scientific Reports, 201812, 8(1), 803-.
24) 胡新俊，徐浩，商一兵，郭丽华，宋丽，张胡平，岳峰，姜红卫*，郑焙文*, First genome sequence of a blaKPC-2-carrying Citrobacter koseri isolate collected from a patient with diarrhoea, Journal of Global Antimicrobial Resistance, 201812, 15166-168.
25) 黄晨#，郑焙文#，喻玮，牛天水，肖婷婷，张静，肖永红*, Antibacterial effect evaluation of moxalactam against extended-spectrum β-lactamase-producing Escherichia coli and klebsiella pneumoniae with in vitro pharmacokinetics/pharmacodynamics simulation, Infection and Drug Resistance, 2018, 11,103-112.
26) 江夏薇，刘文洪，郑焙文*, Data descriptor: Complete genome sequencing of Comamonas kerstersii 8943, a causative agent for peritonitis, Scientific Data, 2018, 5, 180222.
27) 徐浩#，王鑫#，尉骁，张静，郭丽华，黄晨，江夏薇，李学文，冯友军，郑焙文*, First detection and genomics analysis of KPC-2-producing Citrobacter isolates from river sediments, Environmental Pollution, 201804, 235931-937.
28) 郑焙文#，黄晨#，徐浩，尉骁，张静，王鑫，江夏薇，肖永红*，李兰娟, Complete nucleotide sequences of two KPC-2-encoding plasmids from the same Citrobacter freundii isolate, The Journal of antimicrobial chemotherapy, 201802, 73(2), 531-533.
29) 郑焙文#，徐浩#，尉骁，吕涛，江夏薇，程虹，张静，陈云波，黄晨，肖永红*, Identification and genomic characterization of a KPC-2-, NDM-1- and NDM-5-producing Klebsiella michiganensis isolate, The Journal of antimicrobial chemotherapy, 201802, 73(2), 536-538.
30) 郑焙文#，徐浩#，尉骁，江夏薇，陈云波，黄金伟，黄晨，肖永红*, Low prevalence of MCR-1-producing Klebsiella pneumoniae in bloodstream infections in China, Clinical Microbiology and Infection, 201802, 24(2), 205-206.
31) 郑焙文#，吕涛#，徐浩，尉骁，陈云波，李家花，黄晨，郭丽华，张静，江夏薇，肖永红*，李兰娟, Discovery and characterization of an Escherichia coli ST206 strain producing NDM-5 and MCR-1 from a patient with acute diarrhoea in China, International Journal of Antimicrobial Agents, 201802, 51(2), 273-275.
32) 郑焙文#，尉骁#，徐浩，郭丽华，张静，黄晨，沈萍，江夏薇，肖永红*，李兰娟, Complete genome sequencing and genomic characterization of two Escherichia coli strains co-producing MCR-1 and NDM-1 from bloodstream infection, Scientific Reports, 201712, 7(1), 17885-.
33) 郑焙文#，江夏薇#，程虹，郭丽华，张静，徐浩，尉骁，黄晨，嵇金如，应超群，冯友军，肖永红*，李兰娟*, Genome characterization of two bile-isolated Vibrio fluvialis strains: An insight into pathogenicity and bile salt adaption, Scientific Reports, 201712, 7(1), 11827-.
34) 郑焙文#，黄晨#，徐浩#，郭丽华，张静，王鑫，江夏薇，尉骁，金林峰，李学文，冯友军，肖永红*，李兰娟, Occurrence and genomic characterization of ESBL-producing, MCR-1-harboring Escherichia coli in farming soil, Frontiers in Microbiology, 2017, 12: 2510.
35) 郑焙文#，张静，江夏薇，程虹，嵇金如，肖永红*，李兰娟, Complete nucleotide sequence of pSKLX3330, an IncI1 plasmid carrying blaCTX-M-55 isolated from community-onset Escherichia coli infection, Journal of Global Antimicrobial Resistance, 201712, 11120-122.
36) 董慧慧#，陈俭#，Hastings A.K，郭丽华，郑焙文*, Complete genome sequence and comparative analysis of Staphylococcus condimenti DSM 11674, a potential starter culture isolated from soy sauce mash, Frontiers in Bioengineering and Biotechnology, 2017, 5: 56.
37) 沈萍#，樊建中#，郭丽华，李家花，李昂，张静，应超群，嵇金如，徐浩，肖永红，郑焙文* Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL), Annals of clinical microbiology and antimicrobials, 201705, 16(1), 37-.
38) 郑焙文#，徐浩，李昂，嵇金如，王瑜，肖永红*，李兰娟, Community-associated methicillin-resistant Staphylococcus aureus pneumonia in China, The Lancet Infectious Diseases, 201701, 17(7),26.
39) 郑焙文#，张凡#，柴陆军，喻高明，舒福昌，王正良，苏三宝，向廷生，张忠智，候读杰，佘跃惠*, Draft genome sequence of Paenibacillus sp. strain A2, Standards in Genomic Sciences, 201612, 11(1), 9-.
40) 郑焙文#，董慧慧#，徐浩#，吕继芳，张静，江夏薇，杜宇，肖永红*，李兰娟, Coexistence of MCR-1 and NDM-1 in Clinical Escherichia coli Isolates, Clinical Infectious Diseases, 201611, 63(10), 1393-1395.
41) 王婷婷#，江夏薇#，冯春燕，李昂，董慧慧，吴绍强，郑焙文*, Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31, Gut Pathogens, 201610, 8, 1, 1-8.
42) 陈俭#，董慧慧#，Murfin K.E，冯春燕，吴绍强*，郑焙文*, Active site analysis of sortase A from Staphylococcus simulans indicates function in cleavage of putative cell wall proteins, Biochemical and Biophysical Research Communications, 201609, 478, 4, 1653-1659.
43) 郑焙文#，江夏薇#，徐泽明，方云辉，李兰娟*, Characterization of a novel metallo-β-lactamases fold hydrolase from Pelagibacterium halotolerans, a marine halotolerant bacterium isolated from East China Sea, Extremophiles, 201601, 20(1), 37-44.
奖励情况
1) 郑焙文（2/9），国家细菌耐药监测体系建设与应用,浙江省科技厅，浙江省科学技术进步奖，二等奖，2018（肖永红，郑焙文，周凯，沈萍，陈云波，李兰娟，嵇金如，徐浩，张静）
2) 郑焙文（2/14），国家细菌耐药监测体系建设与应用,浙江省卫健委，浙江省医药卫生科技奖，一等奖，2018（肖永红，郑焙文，周凯，沈萍，陈云波，李兰娟，嵇金如，徐浩，张静，赵丽娜，李苏娟，孔海深，陈晓，张伟丽）
郑焙文（2/9），One health 细菌耐药防控技术体系研究与应用，浙江省科技厅，浙江省科学技术进步奖，二等奖，2020（肖永红，郑焙文，罗琦霞，沈萍，陈云波，嵇金如，迟小惠，徐浩，肖婷婷）
社会任职
l 中华医学会感染病学分会细菌真菌病学组副组长
l 中国微生物学会医学微生物学与免疫学专业委员会首届青年委员
l 中华预防医学会感染病防控分会首届青年委员
l 《中华传染病杂志》通讯编委
l 《中国抗生素杂志》编委
l 《中国感染控制杂志》青年编委
l BMC Genomics (IF: 3.969) Editorial Board Members
l Front Microbiol (IF: 5.64)、Front Cell Infect Microbiol (IF: 5.505)、Front Med (IF: 5.09)、Front Public Health (IF: 3.709) Reviewer Editor
Environ Pollut (IF: 8.071)、Sci Total Environ (IF: 7.963)、Emerg Microbes Infect (IF: 7.163)、J Antimicrob Chemother (IF: 5.79)、Antimicrob Agents Chemother (IF: 5.191)、Int J Antimicrob Agents (IF: 5.283)、ACS Infectious Diseases (IF: 5.084)、Front Microbiol (IF: 5.64)、Front Cell Infect Microbiol (IF: 5.505)、Evol Appl (IF: 5.183)、Sci Rep (IF: 4.379)、Front Med (IF: 5.09)、Antimicrob Resist Infect Control (IF: 4.887)、BMC Genomics (IF: 3.969)、Infect Drug Resist (IF: 4.003)、Microb Pathog (IF: 3.738)、J Glob Antimicrob Resist (IF: 4.035)、Ann Clin Microbiol Antimicrob (IF: 2.705)、Microb Drug Resist (IF: 3.431)、J Zhejiang Univ Sci B (3.066)、Mar Genomics (IF: 1.71)、J Food Saf (IF: 1.953)等20余种SCI 期刊，以及《微生物学报》、《生物工程学报》、《中华传染病杂志》、《微生物学通报》、《中国抗生素杂志》、《中国感染控制杂志》、《浙江大学学报（医学版）》等中文一级/核心期刊审稿人
