个人简介
郑六海博士，特聘研究员。长期从事肿瘤靶向治疗研究，聚焦新型抗肿瘤靶点的发现与应用，细胞疗法的改造优化。主持国自然青年基金1项，参与多个国家自然科学基金项目。研究成果发表于Acta Pharmaceutica Sinica B、Journal for ImmunoTherapy of Cancer、Journal of Controlled Release、Cell Reports Medicine等国际知名期刊。
研究方向
抗肿瘤靶点开发与应用；细胞疗法优化。
成果奖项：（近五年主要成果及奖励情况）
1. Liuhai Zheng 1, 2,#, Youbing Ding 1, 3,#, Xiaolong Xu 1 2,#, Huifang Wang 1, 2,#, Guangwei Shi 4, Yang Li 1, Yuanqiao He 5, 6, Yue Gong 1, Xiaodong Zhang 3, Jinxi Wei 1, Zhiyu Dong 1, Jiexuan Li 1, Shanchao Zhao 7, 8, 9, Rui Hou 1, Wei Zhang 1, 10, Jigang Wang 1, 10, 11, 12, 13, 14, Zhijie Li 1. CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers. Acta Pharmaceutica Sinica B. IF. 2025, 15(5):2559-2574.
2. Liuhai Zheng1, 2,#, Huifang Wang1, 2,#, Jihao Zhou1, 3,#, Guangwei Shi1, Jingbo Ma1, Yuke Jiang1, Zhiyu Dong1, Jiexuan Li1, Yuanqiao He4,5, Jichao Sun1, *, Chengchao Xu1,6,7 *, Zhijie Li1, *, Jigang Wang1,8,9,10,11,*. Off-the-Shelf CAR-NK Cells targeting immunogenic cell death marker ERp57 execute robust anti-tumor activity and have a synergistic effect with ICD inducer oxaliplatin. Journal for ImmunoTherapy of Cancer. 2024, 12(7): e008888.
3. Zheng LH#, Wu J#, Hu H#, Cao H#, Xu N#, Chen K, Wen B, Wang H, Yuan H, Xie L, Jiang Y, Li Z, Liang C, Yuan J, Li Z*, Yuan X*, Xiao W*, Wang J*. Single-cell RNA transcriptome landscape of murine liver following systemic administration of mesoporous silica nanoparticles. J Control Release. 2023, 361: 427-442.
4. Liuhai Zheng#, Huifang Wang#, Xueyan Liu#, Chengchao Xu#, Mingxiong Tian, Guangwei Shi, Chongzhi Bai*, Zhijie Li*, Jigang Wang*, Shuwen Liu*. A panel of multivalent nanobodies broadly neutralizing Omicron subvariants and recombinants. Journal of Medical Virology. 2024, 96(3): e29528.
5. Liuhai Zheng#, Qian Zhang#, Piao Luo#, Fei Shi#, Ying Zhang, Xiaoxue He, Yehai An, Guangqing Cheng, Xiaoyan Pan*, Zhijie Li*, Boping Zhou*, Jigang Wang*. Chemical Proteomics Approaches for Screening Small Molecule Inhibitors Covalently Binding to SARS-Cov-2. Advanced Biology. 2024, 8(11): e2300612.
6. Huifang Wang#, Liuhai Zheng#, Chuanbin Yang#, Lin Jia#, Runhua Zhou, Hongda Liu, Yafang Dong, Xiaolong Xu, Guangwei Shi, Jialu Yang, Yang Li, Haitao Yuan, Jinpeng Cen, Guiming Zhang, Le Yu, Tianqi Guo, Haibo Jiang, Yawei Liu*, Xijun Wang*, Zhijie Li*, Jigang Wang*. Tumor microenvironment reprogramming with synthetic pro-interleukin-15 and photothermal therapy mediated by bioengineered probiotics. Cell Reports Medicine. IF: 12.1. 2025, 6(6): 102191.
社会任职
无
