出诊信息
注：出诊时间如有变化，以当日挂号为准| 门诊时间 | 门诊地点 |
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个人简介
李雪芬，浙江大学医学院附属第一医院主任技师，医学博士，执业医师。从事临床检验学诊断、科研和教学工作30余年，主要致力于临床治疗性疫苗、感染性疾病发病机制和检验新技术研究。近年来，作为项目负责人承担了国家自然科学基金面上项目、传染病国家科技重大专项子课题、浙江省自然科学基金课题等多项课题。在J Infect、Cellular Immumonoly、Vaccine、Clin Rev Allergy Immunol、Clin Sci、Cell Death Dis等国际医学杂志上发表相关论文40余篇，参编《中华医学百科全书》、《治疗性疫苗》、《检验医学高级教程》等专著，研究成果获得浙江省自然科学一等奖。
专业擅长
感染性疾病特别是慢性乙型肝炎的分子诊断、发病机制及免疫应答研究
研究方向
感染免疫
成果奖项：（近五年主要成果及奖励情况）
1. Huang L, Ye B, Cao F, Ruan B, Li X. Single-Cell Atlas of the Peripheral Immune Response in Patients With Chronic Hepatitis B. J Med Virol. 2025; 97(5):e70360.
2. Zhong X, Zhou H, Dong Y, Li X. Clinical Application of RNA Simultaneous Amplification and Testing for Pathogens Associated with Urogenital Infections. Clin Lab. 2025;71(2)：201-207.
3. Yang J, Xu S, Cheng J, Yin X, Yan D, Li X. CXCL10 and its receptor in patients with chronic hepatitis B and their ability to predict HBeAg seroconversion during antiviral treatment with TDF. J Med Virol. 2024;96(3):e29516.
4. Yang J, Cao D, Tang R, Li X. Chemokines and Their Receptors in Hepatitis B Virus Infection: A Comprehensive Review. Journal of Cellular Immunology. 2024;6(4):171-181.
5. Li X, Zhu Q, Ye B, Zhu C, Dong Y, Ni Q. JNK/c-Jun Pathway Activation is Essential for HBx-induced IL-35 Elevation to Promote Persistent HBV Infection. J Clin Lab Anal. 2023 ;e24860.
6. Li Y, Wang C, Yin X, Jiang L, Li X, Yang J. Profile and clinical significance of interferon gamma-inducible protein-10 (IP-10) and its receptor in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol. 2023;149(16): 14879-14888.
7. Ye B, Shen Y, Chen H, Lin S, Mao W, Dong Y, Li X. Differential proteomic analysis of plasma-derived exosomes as diagnostic biomarkers for chronic HBV-related liver disease. Sci Rep. 2022;12(1):14428.
8. Li X, Liu X, Wang W. IL-35: A novel immunomodulator in hepatitis B virus-related liver diseases. Front Cell Dev Biol. 2021; 9: 614847.
